Cunha BA, Burillo A, Bouza E. Legionnaires’ disease. Lancet. 2016;387(10016):376-85.
Isberg RR, O’Connor TJ, Heidtman M. The Legionella pneumophila replication vacuole: making a cosy niche inside host cells. Nat Rev Microbiol. 2009;7(1):13–24.
Article
CAS
PubMed
Google Scholar
Vincent CD, Friedman JR, Jeong KC, Buford EC, Miller JL, Vogel JP. Identification of the core transmembrane complex of the Legionella Dot/Icm type IV secretion system. Mol Microbiol. 2006;62(5):1278–91.
Article
CAS
PubMed
Google Scholar
Sexton JA, Pinkner JS, Roth R, Heuser JE, Hultgren SJ, Vogel JP. The Legionella pneumophila PilT homologue DotB exhibits ATPase activity that is critical for intracellular growth. J Bacteriol. 2004;186(6):1658–66.
Article
CAS
PubMed
PubMed Central
Google Scholar
Sexton JA, Yeo HJ, Vogel JP. Genetic analysis of the Legionella pneumophila DotB ATPase reveals a role in type IV secretion system protein export. Mol Microbiol. 2005;57(1):70–84.
Article
CAS
PubMed
Google Scholar
Dumenil G, Montminy TP, Tang M, Isberg RR. IcmR-regulated membrane insertion and efflux by the Legionella pneumophila IcmQ protein. J Biol Chem. 2004;279(6):4686–95.
Article
CAS
PubMed
Google Scholar
Bitar DM, Molmeret ML, Abu Kwalk Y. Structure-function analysis of the C-terminus of IcmT of Legionella pneumophila in pore formation-mediated egress from macrophages. FEMS Microbiol Lett. 2005;242(1):177–84.
Article
CAS
PubMed
Google Scholar
Vincent CD, Friedman JR, Jeong KC, Sutherland MC, Vogel JP. Identification of the DotL coupling protein subcomplex of the Legionella Dot/Icm type IV secretion system. Mol Microbiol. 2012;85(2):378–91.
Article
CAS
PubMed
PubMed Central
Google Scholar
Buscher BA, Conover GM, Miller JL, Vogel SA, Meyers SN, Isberg RR, Vogel JP. The DotL protein, a member of the TraG-coupling protein family, is essential for Viability of Legionella pneumophila strain Lp02. J Bacteriol. 2005;187(9):2927–38.
Article
CAS
PubMed
PubMed Central
Google Scholar
Donaldson JG, Jackson CL. Regulators and effectors of the ARF GTPases. Curr Opin Cell Biol. 2000;12(4):475–82.
Article
CAS
PubMed
Google Scholar
Price CT, Al-Quadan T, Santic M, Rosenshine I, Abu Kwaik Y. Host proteasomal degradation generates amino acids essential for intracellular bacterial growth. Science. 2011;334(6062):1553–7.
Article
CAS
PubMed
Google Scholar
Al-Quadan T, Price CT, Abu Kwaik Y. Exploitation of evolutionarily conserved amoeba and mammalian processes by Legionella. Trends Microbiol. 2012;20(6):299–306.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hervet E, Charpentier X, Vianney A, Lazzaroni JC, Gilbert C, Atlan D, Doublet P. Protein kinase LegK2 is a type IV secretion system effector involved in endoplasmic reticulum recruitment and intracellular replication of Legionella pneumophila. Infect Immun. 2011;79(5):1936–50.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hubber A, Roy CR. Modulation of host cell function by Legionella pneumophila type IV effectors. Annu Rev Cell Dev Biol. 2010;26:261–83.
Article
CAS
PubMed
Google Scholar
Isaac DT, Laguna RK, Valtz N, Isberg RR. MavN is a Legionella pneumophila vacuole-associated protein required for efficient iron acquisition during intracellular growth. Proc Natl Acad Sci U S A. 2015;112(37):E5208–17.
Article
CAS
PubMed
PubMed Central
Google Scholar
Harding CR, Stoneham CA, Schuelein R, Newton H, Oates CV, Hartland EL, Schroeder GN, Frankel G. The Dot/Icm effector SdhA is necessary for virulence of Legionella pneumophila in Galleria mellonella and A/J mice. Infect Immun. 2013;81(7):2598–605.
Article
CAS
PubMed
PubMed Central
Google Scholar
Gottesman S. Proteolysis in bacterial regulatory circuits. Annu Rev Cell Dev Biol. 2003;19:565–87.
Article
CAS
PubMed
Google Scholar
Kress W, Mutschler H, Weber-Ban E. Both ATPase domains of ClpA are critical for processing of stable protein structures. J Biol Chem. 2009;284(45):31441–52.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wang J, Hartling JA, Flanagan JM. The structure of ClpP at 2.3 A resolution suggests a model for ATP-dependent proteolysis. Cell. 1997;91(4):447–56.
Article
CAS
PubMed
Google Scholar
Zolkiewski M. A camel passes through the eye of a needle: protein unfolding activity of Clp ATPases. Mol Microbiol. 2006;61(5):1094–100.
Article
CAS
PubMed
PubMed Central
Google Scholar
Msadek T, Dartois V, Kunst F, Herbaud ML, Denizot F, Rapoport G. ClpP of Bacillus subtilis is required for competence development, motility, degradative enzyme synthesis, growth at high temperature and sporulation. Mol Microbiol. 1998;27(5):899–914.
Article
CAS
PubMed
Google Scholar
Frees D, Ingmer H. ClpP participates in the degradation of misfolded protein in Lactococcus lactis. Mol Microbiol. 1999;31(1):79–87.
Article
CAS
PubMed
Google Scholar
Gaillot O, Pellegrini E, Bregenholt S, Nair S, Berche P. The ClpP serine protease is essential for the intracellular parasitism and virulence of Listeria monocytogenes. Mol Microbiol. 2000;35(6):1286–94.
Article
CAS
PubMed
Google Scholar
Kock H, Gerth U, Hecker M. The ClpP peptidase is the major determinant of bulk protein turnover in Bacillus subtilis. J Bacteriol. 2004;186(17):5856–64.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hamoen LW, Venema G, Kuipers OP. Controlling competence in Bacillus subtilis: shared use of regulators. Microbiology. 2003;149(Pt 1):9–17.
Article
CAS
PubMed
Google Scholar
Frees D, Chastanet A, Qazi S, Sorensen K, Hill P, Msadek T, Ingmer H. Clp ATPases are required for stress tolerance, intracellular replication and biofilm formation in Staphylococcus aureus. Mol Microbiol. 2004;54(5):1445–62.
Article
CAS
PubMed
Google Scholar
Gaillot O, Bregenholt S, Jaubert F, Di Santo JP, Berche P. Stress-induced ClpP serine protease of Listeria monocytogenes is essential for induction of listeriolysin O-dependent protective immunity. Infect Immun. 2001;69(8):4938–43.
Article
CAS
PubMed
PubMed Central
Google Scholar
Li XH, Zeng YL, Gao Y, Zheng XC, Zhang QF, Zhou SN, Lu YJ. The ClpP protease homologue is required for the transmission traits and cell division of the pathogen Legionella pneumophila. BMC Microbiol. 2010;10:54.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hilbi H, Segal G, Shuman HA. Icm/dot-dependent upregulation of phagocytosis by Legionella pneumophila. Mol Microbiol. 2001;42(3):603–17.
Article
CAS
PubMed
Google Scholar
Joshi AD, Sturgill-Koszycki S, Swanson MS. Evidence that Dot-dependent and -independent factors isolate the Legionella pneumophila phagosome from the endocytic network in mouse macrophages. Cell Microbiol. 2001;3(2):99–114.
Article
CAS
PubMed
Google Scholar
Gal-Mor O, Zusman T, Segal G. Analysis of DNA regulatory elements required for expression of the Legionella pneumophila icm and dot virulence genes. J Bacteriol. 2002;184(14):3823–33.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ren T, Zamboni DS, Roy CR, Dietrich WF, Vance RE. Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity. PLoS Pathog. 2006;2(3):e18.
Article
PubMed
PubMed Central
Google Scholar
Santic M, Asare R, Doric M, Abu Kwaik Y. Host-dependent trigger of caspases and apoptosis by Legionella pneumophila. Infect Immun. 2007;75(6):2903–13.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bardill JP, Miller JL, Vogel JP. IcmS-dependent translocation of SdeA into macrophages by the Legionella pneumophila type IV secretion system. Mol Microbiol. 2005;56(1):90–103.
Article
CAS
PubMed
Google Scholar
Coers J, Kagan JC, Matthews M, Nagai H, Zuckman DM, Roy CR. Identification of Icm protein complexes that play distinct roles in the biogenesis of an organelle permissive for Legionella pneumophila intracellular growth. Mol Microbiol. 2000;38(4):719–36.
Article
CAS
PubMed
Google Scholar
Vincent CD, Vogel JP. The Legionella pneumophila IcmS-LvgA protein complex is important for Dot/Icm-dependent intracellular growth. Mol Microbiol. 2006;61(3):596–613.
Article
CAS
PubMed
Google Scholar
Cambronne ED, Roy CR. The Legionella pneumophila IcmSW complex interacts with multiple Dot/Icm effectors to facilitate type IV translocation. PLoS Pathog. 2007;3(12):e188.
Article
PubMed
PubMed Central
Google Scholar
Frees D, Qazi SN, Hill PJ, Ingmer H. Alternative roles of ClpX and ClpP in Staphylococcus aureus stress tolerance and virulence. Mol Microbiol. 2003;48(6):1565–78.
Article
CAS
PubMed
Google Scholar
Ibrahim YM, Kerr AR, Silva NA, Mitchell TJ. Contribution of the ATP-dependent protease ClpCP to the autolysis and virulence of Streptococcus pneumoniae. Infect Immun. 2005;73(2):730–40.
Article
CAS
PubMed
PubMed Central
Google Scholar
Jackson MW, Silva-Herzog E, Plano GV. The ATP-dependent ClpXP and Lon proteases regulate expression of the Yersinia pestis type III secretion system via regulated proteolysis of YmoA, a small histone-like protein. Mol Microbiol. 2004;54(5):1364–78.
Article
CAS
PubMed
Google Scholar
Knudsen GM, Olsen JE, Aabo S, Barrow P, Rychlik I, Thomsen LE. ClpP deletion causes attenuation of Salmonella Typhimurium virulence through mis-regulation of RpoS and indirect control of CsrA and the SPI genes. Microbiology. 2013;159(Pt 7):1497–509.
Article
CAS
PubMed
Google Scholar
Sutherland MC, Nguyen TL, Tseng V, Vogel JP. The Legionella IcmSW complex directly interacts with DotL to mediate translocation of adaptor-dependent substrates. PLoS Pathog. 2012;8(9):e1002910.
Article
CAS
PubMed
PubMed Central
Google Scholar
Nagai H, Cambronne ED, Kagan JC, Amor JC, Kahn RA, Roy CR. A C-terminal translocation signal required for Dot/Icm-dependent delivery of the Legionella RalF protein to host cells. Proc Natl Acad Sci U S A. 2005;102(3):826–31.
Article
CAS
PubMed
Google Scholar
Jeong KC, Sutherland MC, Vogel JP. Novel export control of a Legionella Dot/Icm substrate is mediated by dual, independent signal sequences. Mol Microbiol. 2015;96(1):175–88.
Article
CAS
PubMed
Google Scholar
Hales LM, Shuman HA. The Legionella pneumophila rpoS gene is required for growth within Acanthamoeba castellanii. J Bacteriol. 1999;181(16):4879–89.
CAS
PubMed
PubMed Central
Google Scholar
Molofsky AB, Swanson MS. Differentiate to thrive: lessons from the Legionella pneumophila life cycle. Mol Microbiol. 2004;53(1):29–40.
Article
CAS
PubMed
Google Scholar
Gonzalez M, Rasulova F, Maurizi MR, Woodgate R. Subunit-specific degradation of the UmuD/D’ heterodimer by the ClpXP protease: the role of trans recognition in UmuD’ stability. EMBO J. 2000;19(19):5251–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Michel A, Agerer F, Hauck CR, Herrmann M, Ullrich J, Hacker J, Ohlsen K. Global regulatory impact of ClpP protease of Staphylococcus aureus on regulons involved in virulence, oxidative stress response, autolysis, and DNA repair. J Bacteriol. 2006;188(16):5783–96.
Article
CAS
PubMed
PubMed Central
Google Scholar
Savijoki K, Ingmer H, Frees D, Vogensen FK, Palva A, Varmanen P. Heat and DNA damage induction of the LexA-like regulator HdiR from Lactococcus lactis is mediated by RecA and ClpP. Mol Microbiol. 2003;50(2):609–21.
Article
CAS
PubMed
Google Scholar
Xu L, Shen X, Bryan A, Banga S, Swanson MS, Luo ZQ. Inhibition of host vacuolar H + −ATPase activity by a Legionella pneumophila effector. PLoS Pathog. 2010;6(3):e1000822.
Article
PubMed
PubMed Central
Google Scholar
Sturgill-Koszycki S, Swanson MS. Legionella pneumophila replication vacuoles mature into acidic, endocytic organelles. J Exp Med. 2000;192(9):1261–72.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bachman MA, Swanson MS. RpoS co-operates with other factors to induce Legionella pneumophila virulence in the stationary phase. Mol Microbiol. 2001;40(5):1201–14.
Article
CAS
PubMed
Google Scholar
Moffat JF, Tompkins LS. A quantitative model of intracellular growth of Legionella pneumophila in Acanthamoeba castellanii. Infect Immun. 1992;60(1):296–301.
CAS
PubMed
PubMed Central
Google Scholar
LeBlanc JJ, Davidson RJ, Hoffman PS. Compensatory functions of two alkyl hydroperoxide reductases in the oxidative defense system of Legionella pneumophila. J Bacteriol. 2006;188(17):6235–44.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ninio S, Zuckman-Cholon DM, Cambronne ED, Roy CR. The Legionella IcmS-IcmW protein complex is important for Dot/Icm-mediated protein translocation. Mol Microbiol. 2005;55:912–926.
Cormack BP, Valdivia RH, Falkow S. FACS-optimized mutants of the green fluorescent protein (GFP). Gene. 1996;173(1 Spec No):33–8.
Article
CAS
PubMed
Google Scholar
Hammer BK, Swanson MS. Co-ordination of legionella pneumophila virulence with entry into stationary phase by ppGpp. Mol Microbiol. 1999;33(4):721–31.
Article
CAS
PubMed
Google Scholar
Swanson MS, Isberg RR. Identification of Legionella pneumophila mutants that have aberrant intracellular fates. Infect Immun. 1996;64(7):2585–94.
CAS
PubMed
PubMed Central
Google Scholar
Kohler R, Bubert A, Goebel W, Steinert M, Hacker J, Bubert B. Expression and use of the green fluorescent protein as a reporter system in Legionella pneumophila. Mol Gen Genet. 2000;262(6):1060–9.
Article
CAS
PubMed
Google Scholar