Articles

Changes of gut microbiome composition and metabolites associated with hypertensive heart failure rats

The potential role of the gut microbiome (GM) in heart failure (HF) had recently been revealed. However, the underlying mechanisms of the GM and fecal metabolome in HF have not been characterized. The Dahl sal...

Authors: Lin Li, Sen-jie Zhong, Si-yuan Hu, Bin Cheng, Hong Qiu and Zhi-xi Hu

Deviations in the gut microbiota of neonates affected by maternal group B Streptococcus colonization

Group B Streptococcus (GBS) infection is the leading cause of septicemia, meningitis, and pneumonia in neonates. Aberrant gut colonization in early life may predispose children to various diseases in adulthood...

Authors: Yue-feng Li, Xue-lei Gong, Su-xiang Chen, Kejian Wang and Yan-hua Jiang

Prevalence, population structure, distribution of serotypes, pilus islands and resistance genes among erythromycin-resistant colonizing and invasive Streptococcus agalactiae isolates recovered from pregnant and non-pregnant women in Isfahan, Iran

The information on antibiotic resistance and molecular features of Group B Streptococcus (GBS) are essential for epidemiological purposes as well as vaccine development. Therefore, we aimed to assess the antimicr...

Authors: Tahereh Motallebirad, Hossein Fazeli, Ataollah Ghahiri, Dariush Shokri, Saba Jalalifar, Sharareh Moghim and Bahram Nasr Esfahani

Ecological and network analyses identify four microbial species with potential significance for the diagnosis/treatment of ulcerative colitis (UC)

Ulcerative colitis (UC) is one of the primary types of inflammatory bowel disease (IBD), the occurrence of which has been increasing worldwide. Although IBD is an intensively studied human microbiome-associate...

Authors: Wendy Li, Yang Sun, Lin Dai, Hongju Chen, Bin Yi, Junkun Niu, Lan Wang, Fengrui Zhang, Juan Luo, Kunhua Wang, Rui Guo, Lianwei Li, Quan Zou, Zhanshan (Sam) Ma and Yinglei Miao

Tauroursodeoxycholic acid prevents Burkholderia pseudomallei-induced endoplasmic reticulum stress and is protective during melioidosis in mice

Burkholderia pseudomallei, a facultative intracellular bacterium, is the aetiological agent of melioidosis that is responsible for up to 40% sepsis-related mortality in epidemic areas. However, no effective vacci...

Authors: Siqi Yuan, Yao Fang, Mengling Tang, Zhiqiang Hu, Chenglong Rao, Jiangao Chen, Yupei Xia, Meijuan Zhang, Jingmin Yan, Bin Tang, Xiaoyi He, Jianping Xie, Xuhu Mao and Qian Li

Detection and characterization of carbapenem resistant Gram‐negative bacilli isolates recovered from hospitalized patients at Soba University Hospital, Sudan

Antimicrobial resistance (AMR) poses a complex threat to global health security and universal health coverage. Recently, nosocomial infections with carbapenemase-producing Gram-negative bacilli (GNB) is increa...

Authors: Hana S. Elbadawi, Kamal M. Elhag, Elsheikh Mahgoub, Hisham N. Altayb, Francine Ntoumi, Linzy Elton, Timothy D. McHugh, John Tembo, Giuseppe Ippolito, Abdinasir Yusuf Osman, Alimuddin Zumla and Muzamil M. Abdel Hamid

Prevalence and antibiotics susceptibility profiles of Streptococcus pyogenes among pediatric patients with acute pharyngitis at Felege Hiwot Comprehensive Specialized Hospital, Northwest Ethiopia

Streptococcus pyogenes (S. pyogenes) is a Gram positive bacterium which is a leading cause of pharyngitis, skin and soft tissue infection and post streptococcal syndromes. Due to lack of β-lactamase enzyme produc...

Authors: Destaw Kebede, Alemale Admas and Daniel Mekonnen

Analysis of culturable airborne fungi in outdoor environments in Tianjin, China

Fungal spores dispersed in the atmosphere may become cause of different pathological conditions and allergies for human beings. A number of studies have been performed to analyze the diversity of airborne fung...

Authors: Yumna Nageen, Michael Dare Asemoloye, Sergei Põlme, Xiao Wang, Shihan Xu, Pramod W. Ramteke and Lorenzo Pecoraro

Comparative genome analysis of multidrug-resistant Pseudomonas aeruginosa JNQH-PA57, a clinically isolated mucoid strain with comprehensive carbapenem resistance mechanisms

The prevalence of clinical multidrug-resistant (MDR) Pseudomonas aeruginosa has been increasing rapidly worldwide over the years and responsible for a wide range of acute and chronic infections with high mortalit...

Authors: Mingju Hao, Wanshan Ma, Xiutao Dong, Xiaofeng Li, Fang Cheng and Yujiao Wang

Sewage and sewage-contaminated environments are the most prominent sources to isolate phages against Pseudomonas aeruginosa

P. aeruginosa is the primary source of hospital-acquired infections. Unfortunately, antibiotic resistance is growing to precariously high levels, making the infections by this pathogen life-threatening and hard t...

Authors: Bahareh Lashtoo Aghaee, Mohammadali Khan Mirzaei, Mohammad Yousef Alikhani and Ali Mojtahedi

Sex differences in the phylum‐level human gut microbiota composition

Evidence was previously provided for sex-related differences in the human gut microbiota composition, and sex-specific discrepancy in hormonal profiles was proposed as a main determinant of these differences. ...

Authors: Alexander Koliada, Vladislav Moseiko, Mariana Romanenko, Oleh Lushchak, Nadiia Kryzhanovska, Vitaly Guryanov and Alexander Vaiserman

Shifting the microbiome of a coral holobiont and improving host physiology by inoculation with a potentially beneficial bacterial consortium

The coral microbiome plays a key role in host health by being involved in energy metabolism, nutrient cycling, and immune system formation. Inoculating coral with beneficial bacterial consortia may enhance the...

Authors: Ying Zhang, Qingsong Yang, Juan Ling, Lijuan Long, Hui Huang, Jianping Yin, Meilin Wu, Xiaoyu Tang, Xiancheng Lin, Yanying Zhang and Junde Dong

Correction to: Aging progression of human gut microbiota

Authors: Congmin Xu, Huaiqiu Zhu and Peng Qiu

Characteristics and variation of fecal bacterial communities and functions in isolated systolic and diastolic hypertensive patients

Hypertension (HTN) is one of the major cardiovascular risk factors, which contributes to increasing target organ damages and cardiovascular morbidity and mortality worldwide. Isolated systolic HTN (ISH) and is...

Authors: Pan Wang, Ying Dong, Kun Zuo, Chunming Han, Jie Jiao, Xinchun Yang and Jing Li

A buffered media system for yeast batch culture growth

Fungi are premier hosts for the high-yield secretion of proteins for biomedical and industrial applications. The stability and activity of these secreted proteins is often dependent on the culture pH. As yeast...

Authors: Rianne C. Prins and Sonja Billerbeck

Decreased abundance of Akkermansia after adrenocorticotropic hormone therapy in patients with West syndrome

Infants suffer from a severe epileptic encephalopathy known as West syndrome (WS). Treatment with adrenocorticotropic hormone (ACTH) indicates the involvement of the gut-brain axis in WS. Several pieces of evi...

Authors: Lu Xu, Dandan Chen, Congying Zhao, Lihua Jiang, Shanshan Mao, Chao Song and Feng Gao

Isolation and genomic characterization of five novel strains of Erysipelotrichaceae from commercial pigs

Members of the Erysipelotrichaceae family have a high abundance in the intestinal tract of mammals, and have been reported to be associated with host metabolic disorders and inflammatory diseases. In our previ...

Authors: Jinyuan Wu, Min Liu, Mengqing Zhou, Lin Wu, Hui Yang, Lusheng Huang and Congying Chen

Metallo-β-lactamase and AmpC genes in Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa isolates from abattoir and poultry origin in Nigeria

Gram-negative bacteria (GNB) including Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae represent the most relevant reservoir of resistance genes such as metallo-β-lactamase (MBL) and AmpC gene...

Authors: Chika Ejikeugwu, Okoro Nworie, Morteza Saki, Hussein O. M. Al-Dahmoshi, Noor S. K. Al-Khafaji, Chika Ezeador, Emmanuel Nwakaeze, Peter Eze, Eniola Oni, Chidiebere Obi, Ifeanyichukwu Iroha, Charles Esimone and Michael U. Adikwu

Genetic variability in multidrug-resistant Mycobacterium tuberculosis isolates from patients with pulmonary tuberculosis in North India

Information on the genetic variability of drug resistant isolates of Mycobacterium tuberculosis is of paramount importance to understand transmission dynamics of disease and to improve TB control strategies. Desp...

Authors: Ajay Vir Singh, Suman Singh, Anjali Yadav, Shweta Kushwah, Rajbala Yadav, Davuluri Kushma Sai and Devendra Singh Chauhan

Helicobacter pylori infection is correlated with the incidence of erosive oral lichen planus and the alteration of the oral microbiome composition

Oral lichen planus (OLP), a common clinical oral disease, is associated with an increased risk of malignant transformation. The mechanism underlying the pathogenesis of OLP is unknown. Oral dysbacteriosis is r...

Authors: Shutong Li, Yangheng Zhang, Zongcheng Yang, Jingyuan Li, Ya Li, Huanjie Li, Wenjuan Li, Jihui Jia, Shaohua Ge and Yundong Sun

Correction to: Effects of continuous cropping of sweet potatoes on the bacterial community structure in rhizospheric soil

An amendment to this paper has been published and can be accessed via the original article.

Authors: Zhiyuan Gao, Yaya Hu, Meikun Han, Junjie Xu, Xue Wang, Lanfu Liu, Zhonghou Tang, Weijing Jiao, Rong Jin, Ming Liu, Zhengjun Guan and Zhimin Ma

Treatment with surfactants enables quantification of translational activity by O-propargyl-puromycin labelling in yeast

Translation is an important point of regulation in protein synthesis. However, there is a limited number of methods available to measure global translation activity in yeast. Recently, O-propargyl-puromycin (O...

Authors: Jennifer Staudacher, Corinna Rebnegger and Brigitte Gasser

Bacterial community in saline farmland soil on the Tibetan plateau: responding to salinization while resisting extreme environments

Salinization damages the health of soil systems and reduces crop yields. Responses of microbial communities to salinized soils and their functional maintenance under high salt stress are valuable scientific pr...

Authors: Yi Qiang Li, Ying Hui Chai, Xu Sheng Wang, Li Ying Huang, Xi Ming Luo, Cheng Qiu, Qing Hai Liu and Xiang Yu Guan

Complete genome sequence analysis of the peanut pathogen Ralstonia solanacearum strain Rs-P.362200

Bacterial wilt caused by Ralstonia solanacearum species complex is an important soil-borne disease worldwide that affects more than 450 plant species, including peanut, leading to great yield and quality losses. ...

Authors: Kun Chen, Lihui Wang, Hua Chen, Chong Zhang, Shanshan Wang, Panpan Chu, Shaokang Li, Huiwen Fu, Tao Sun, Menghan Liu, Qiang Yang, Huasong Zou and Weijian Zhuang

Correction to: Galectins from Onchocerca ochengi and O. volvulus and their immune recognition by Wistar rats, Gudali zebu cattle and human hosts

An amendment to this paper has been published and can be accessed via the original article.

Authors: Ngwafu Nancy Ngwasiri, Norbert W. Brattig, Dieudonné Ndjonka, Eva Liebau, Archile Paguem, Dustin Leusder, Manchang Tanyi Kingsley, Albert Eisenbarth, Alfons Renz and Achukwi Mbunkah Daniel

Resistance‐guided isolation and characterization of antibiotic‐producing bacteria from river sediments

To tackle the problem of antibiotic resistance, an extensive search for novel antibiotics is one of the top research priorities. Around 60% of the antibiotics used today were obtained from the genus Streptomyces....

Authors: Nowreen Arefa, Ashish Kumar Sarker and Md. Ajijur Rahman

In-vitro compatibility assay of indigenous Trichoderma and Pseudomonas species and their antagonistic activities against black root rot disease (Fusarium solani) of faba bean (Vicia faba L.)

Faba bean (Vicia faba L.) cultivation is highly challenged by faba bean black root rot disease (Fusarium solani) in high lands of Ethiopia. To ensure sustainable production of faba beans, searching for eco-friend...

Authors: Alemayehu Dugassa, Tesfaye Alemu and Yitbarek Woldehawariat

Correlation between the spatial distribution and colony size was common for monogenetic bacteria in laboratory conditions

Geographically separated population growth of microbes is a common phenomenon in microbial ecology. Colonies are representative of the morphological characteristics of this structured population growth. Patter...

Authors: Heng Xue, Masaomi Kurokawa and Bei-Wen Ying

Defining the temporal evolution of gut dysbiosis and inflammatory responses leading to hepatocellular carcinoma in Mdr2 −/− mouse model

Emerging evidence implicates the gut microbiome in liver inflammation and hepatocellular carcinoma (HCC) development. We aimed to characterize the temporal evolution of gut dysbiosis, in relation to the phenot...

Authors: J. Behary, A. E. Raposo, N. M. L. Amorim, H. Zheng, L. Gong, E. McGovern, J. Chen, K. Liu, J. Beretov, C. Theocharous, M. T. Jackson, J. Seet-Lee, G. W. McCaughan, E. M. El-Omar and A. Zekry

Efficacy of 16S rRNA variable regions high-resolution melt analysis for bacterial pathogens identification in periprosthetic joint infections

Accurate and rapid identification of microorganisms causing periprosthetic joint infections (PJIs) are necessary for choosing an appropriate antibiotic therapy. Therefore, molecular techniques are suggested fo...

Authors: Samaneh Bourbour, Mohammad Emaneini, Mahmoud Jabalameli, Seyed Mohammad Javad Mortazavi, Mohamad Naghi Tahmasebi, Amirheckmat Taghizadeh, Arash Sharafatvaziri, Reza Beigverdi and Fereshteh Jabalameli

mRNA-Seq reveals the quorum sensing system luxS gene contributes to the environmental fitness of Streptococcus suis type 2

Streptococcus suis type 2 (SS2) is an important zoonotic pathogen. We have previously reported the structure of LuxS protein and found that the luxS gene is closely related to biofilm, virulence gene expression a...

Authors: Jinpeng Li, Yuxin Wang, Yanbin Du, Hui Zhang, Qingying Fan, Liyun Sun, Li Yi, Shaohui Wang and Yang Wang

Proteomic response of Escherichia coli to a membrane lytic and iron chelating truncated Amaranthus tricolor defensin

Plant defensins are a broadly distributed family of antimicrobial peptides which have been primarily studied for agriculturally relevant antifungal activity. Recent studies have probed defensins against Gram-n...

Authors: Tessa B. Moyer, Ashleigh L. Purvis, Andrew J. Wommack and Leslie M. Hicks

Characterization of fosfomycin resistance and molecular epidemiology among carbapenem-resistant Klebsiella pneumoniae strains from two tertiary hospitals in China

Fosfomycin has been proven to be a vital choice to treat infection caused by multidrug resistance bacteria, especially carbapenem-resistant Klebsiella pneumoniae (CRKP). However, fosfomycin resistant cases has be...

Authors: Haichen Wang, Changhang Min, Jun Li, Ting Yu, Yongmei Hu, Qingya Dou and Mingxiang Zou

Meta-analysis suggests the microbiome responds to Evolve and Resequence experiments in Drosophila melanogaster

Experimental evolution has a long history of uncovering fundamental insights into evolutionary processes, but has largely neglected one underappreciated component--the microbiome. As eukaryotic hosts evolve, t...

Authors: Lucas P. Henry and Julien F. Ayroles

A multispecies outbreak of carbapenem-resistant bacteria harboring the bla_KPC gene in a non-classical transposon element

Klebsiella pneumoniae is the most frequent KPC-producing bacteria. The bla_KPC gene is frequently embedded in Tn4401 transposon, and less frequently in non-Tn4401 elements (NTE_KPC) variants I-III. The first case o...

Authors: Aniela Wozniak, Cristian Figueroa, Francisco Moya-Flores, Piero Guggiana, Claudia Castillo, Lina Rivas, José M. Munita and Patricia C. García

Association between aging-dependent gut microbiome dysbiosis and dry eye severity in C57BL/6 male mouse model: a pilot study

While aging is a potent risk factor of dry eye disease, age-related gut dysbiosis is associated with inflammation and chronic geriatric diseases. Emerging evidence have demonstrated that gut dysbiosis contribu...

Authors: Chang Ho Yoon, Jin Suk Ryu, Jayoon Moon and Mee Kum Kim

The rumen eukaryotome is a source of novel antimicrobial peptides with therapeutic potential

The rise of microbial antibiotic resistance is a leading threat to the health of the human population. As such, finding new approaches to tackle these microbes, including development of novel antibiotics is vi...

Authors: Lucy A. Onime, Linda B. Oyama, Benjamin J. Thomas, Jurnorain Gani, Peter Alexander, Kate E. Waddams, Alan Cookson, Narcis Fernandez-Fuentes, Christopher J. Creevey and Sharon A. Huws

Temporal dynamics of the plasma microbiome in recipients at early post-liver transplantation: a retrospective study

Immunosuppression during liver transplantation (LT) enables the prevention and treatment of organ rejection but poses a risk for severe infectious diseases. Immune modulation and antimicrobials affect the plas...

Authors: Toshihiko Okumura, Kazuhiro Horiba, Hideya Kamei, Suguru Takeuchi, Takako Suzuki, Yuka Torii, Jun-ichi Kawada, Yoshiyuki Takahashi, Yasuhiro Ogura, Tomoo Ogi and Yoshinori Ito

Comparative genomic analysis of Mycobacterium intracellulare: implications for clinical taxonomic classification in pulmonary Mycobacterium avium-intracellulare complex disease

Mycobacterium intracellulare is a representative etiological agent of emerging pulmonary M. avium-intracellulare complex disease in the industrialized countries worldwide. The recent genome sequencing of clinical...

Authors: Yoshitaka Tateishi, Yuriko Ozeki, Akihito Nishiyama, Mari Miki, Ryoji Maekura, Yukari Fukushima, Chie Nakajima, Yasuhiko Suzuki and Sohkichi Matsumoto

Effects of continuous cropping of sweet potatoes on the bacterial community structure in rhizospheric soil

Continuous cropping obstacles from sweet potatoes are widespread, which seriously reduce the yield and quality, causing certain economic losses. Bacteria of rhizospheric soil are the richest and are associated...

Authors: Zhiyuan Gao, Yaya Hu, Meikun Han, Junjie Xu, Xue Wang, Lanfu Liu, Zhonghou Tang, Weijing Jiao, Rong Jin, Ming Liu, Zhengjun Guan and Zhimin Ma

Molecular characterisation of Mycobacterium avium subsp. paratuberculosis in Australia

Mycobacterium avium subsp. paratuberculosis (Map) causes Johne’s disease (JD), a chronic enteritis widespread in ruminants, resulting in substantial economic losses, especially to the dairy industry. Understandin...

Authors: Rachel Hodgeman, Rachel Mann, Keith Savin, Noel Djitro, Simone Rochfort and Brendan Rodoni

The profiling of microbiota in vaginal swab samples using 16S rRNA gene sequencing and IS-pro analysis

16S rRNA gene sequencing is currently the most common way of determining the composition of microbiota. This technique has enabled many new discoveries to be made regarding the relevance of microbiota to the h...

Authors: M. Singer, R. Koedooder, M. P. Bos, L. Poort, S. Schoenmakers, P. H. M. Savelkoul, J. S. E. Laven, J. D. de Jonge, S. A. Morré and A. E. Budding

GroEL protein of the Leptospira spp. interacts with host proteins and induces cytokines secretion on macrophages

Leptospirosis is a zoonotic disease caused by infection with spirochetes from Leptospira genus. It has been classified into at least 17 pathogenic species, with more than 250 serologic variants. This wide distrib...

Authors: Joana Dias Ho, Luiz Eduardo Massao Takara, Denize Monaris, Aline Patrícia Gonçalves, Antonio Francisco Souza-Filho, Gisele Oliveira de Souza, Marcos Bryan Heinemann, Paulo Lee Ho and Patrícia Antonia Estima Abreu

Bacterial community structure alterations within the colorectal cancer gut microbiome

Colorectal cancer is a leading cause of cancer-related deaths worldwide. The human gut microbiome has become an active area of research for understanding the initiation, progression, and treatment of colorecta...

Authors: Mark Loftus, Sayf Al-Deen Hassouneh and Shibu Yooseph

Diversity and characterization of temperate bacteriophages induced in Pasteurella multocida from different host species

Bacteriophages play important roles in the evolution of bacteria and in the emergence of new pathogenic strains by mediating the horizontal transfer of virulence genes. Pasteurella multocida is responsible for di...

Authors: Rezheen F. Abdulrahman and Robert L. Davies

Azithromycin and the microbiota of cystic fibrosis sputum

Azithromycin is commonly prescribed drug for individuals with cystic fibrosis (CF), with demonstrated benefits in reducing lung function decline, exacerbation occurrence and improving nutrition. As azithromyci...

Authors: Nicole Acosta, Christina S. Thornton, Michael G. Surette, Ranjani Somayaji, Laura Rossi, Harvey R. Rabin and Michael D. Parkins

EHEC O111:H8 strain and norovirus GII.4 Sydney [P16] causing an outbreak in a daycare center, Brazil, 2019

This study describes the investigation of an outbreak of diarrhea, hemorrhagic colitis (HC), and hemolytic uremic syndrome (HUS) at a daycare center in southeastern Brazil, involving fourteen children, six sta...

Authors: Liliana Cruz Spano, Caroline Gastaldi Guerrieri, Lays Paula Bondi Volpini, Ricardo Pinto Schuenck, Jaqueline Pegoretti Goulart, Elizabeth Boina, Celia Regina Nascimento Recco, Rodrigo Ribeiro-Rodrigues, Luís Fernando dos Santos and Tulio Machado Fumian

Population structure and uropathogenic potential of extended-spectrum cephalosporin-resistant Escherichia coli from retail chicken meat

Food-producing animals and their products are considered a source for human acquisition of antimicrobial resistant (AMR) bacteria, and poultry are suggested to be a reservoir for Escherichia coli resistant to ext...

Authors: May Linn Buberg, Solveig Sølverød Mo, Camilla Sekse, Marianne Sunde, Yngvild Wasteson and Ingun Lund Witsø

Changes in the gut microbiome community of nonhuman primates following radiation injury

Composition and maintenance of the microbiome is vital to gut homeostasis. However, there is limited knowledge regarding the impact of high doses of radiation, which can occur as a result of cancer radiation t...

Authors: Raj Kalkeri, Kevin Walters, William Van Der Pol, Braden C. McFarland, Nathan Fisher, Fusataka Koide, Casey D. Morrow and Vijay K. Singh

Characterisation of IncI1 plasmids associated with change of phage type in isolates of Salmonella enterica serovar Typhimurium

Acquisition of IncI1 plasmids by members of the Enterobacteriaceae sometimes leads to transfer of antimicrobial resistance and colicinogeny as well as change of phage type in Salmonella Typhimurium. Isolates of S...

Authors: Lester Hiley, Rikki M. A. Graham and Amy V. Jennison