Articles
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Citation: BMC Microbiology 2002 2:10
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Antibodies against prM protein distinguish between previous infection with dengue and Japanese encephalitis viruses.
In Southeast Asia, dengue viruses often co-circulate with other flaviviruses such as Japanese encephalitis virus, and due to the presence of shared antigenic epitopes it is often difficult to use serological m...
Citation: BMC Microbiology 2002 2:9 -
The methionine salvage pathway in Bacillus subtilis
Polyamine synthesis produces methylthioadenosine, which has to be disposed of. The cell recycles it into methionine through methylthioribose (MTR). Very little was known about MTR recycling for methionine salv...
Citation: BMC Microbiology 2002 2:8 -
Biofilm formation by nontypeable Haemophilus influenzae: strain variability, outer membrane antigen expression and role of pili
Nontypeable Haemophilus influenzae is an important cause of otitis media in children and lower respiratory tract infection in adults with chronic obstructive pulmonary disease (COPD). Several lines of evidence su...
Citation: BMC Microbiology 2002 2:7 -
First isolation of the enterohaemorrhagic Escherichia coli O145:H- from cattle in feedlot in Argentina
Enterohaemorrhagic Escherichia coli (EHEC) is considered to be common cause of haemorrhagic colitis (HC), thrombotic thrombocytopenic purpura and haemolytic uraemic syndrome (HUS) in humans. In a previous paper, ...
Citation: BMC Microbiology 2002 2:6 -
Production of Diamino propionic acid ammonia lyase by a new strain of Salmonella typhimurium PU011
Seeds of the legume plant Lathyrus sativus, which is grown in arid and semi arid tropical regions, contain Diamino Propionic acid (DAP). DAP is a neurotoxin, which, when consumed, causes a disease called Lathy...
Citation: BMC Microbiology 2002 2:5 -
Evaluation of amplified rDNA restriction analysis (ARDRA) for the identification of cultured mycobacteria in a diagnostic laboratory
The development of DNA amplification for the direct detection of M. tuberculosis from clinical samples has been a major goal of clinical microbiology during the last ten years. However, the limited sensitivity of...
Citation: BMC Microbiology 2002 2:4 -
Serovar distribution of a DNA sequence involved in the antigenic relationship between Leptospira and equine cornea
Horses infected with Leptospira present several clinical disorders, one of them being recurrent uveitis. A common endpoint of equine recurrent uveitis is blindness. Serovar pomona has often been incriminated, alt...
Citation: BMC Microbiology 2002 2:3 -
Killing of Mycobacterium avium subspecies paratuberculosis within macrophages
Mycobacterium avium subspecies paratuberculosis (M. paratuberculosis) is a facultative intracellular pathogen that resides within host macrophages during infection of ruminant animals. We examined survival of M. ...
Citation: BMC Microbiology 2002 2:2 -
The mechanisms responsible for 2-dimensional pattern formation in bacterial macrofiber populations grown on solid surfaces: fiber joining and the creation of exclusion zones
When Bacillus subtilis is cultured in a complex fluid medium under conditions where cell separation is suppressed, populations of multicellular macrofibers arise that mature into ball-like structures. The final s...
Citation: BMC Microbiology 2002 2:1 -
Phenotypic silencing of cytoplasmic genes using sequence-specific double-stranded short interfering RNA and its application in the reverse genetics of wild type negative-strand RNA viruses
Post-transcriptional gene silencing (PTGS) by short interfering RNA has opened up new directions in the phenotypic mutation of cellular genes. However, its efficacy on non-nuclear genes and its effect on the i...
Citation: BMC Microbiology 2001 1:34 -
Mouse skin passage of a Streptococcus pyogenes Tn917 mutant of sagA/pel restores virulence, beta-hemolysis and sagA/pel expression without altering the position or sequence of the transposon
Streptolysin S (SLS), the oxygen-stable hemolysin of Streptococcus pyogenes, has recently been shown to be encoded by the sagA/pel gene. Mutants lacking expression of this gene were less virulent in a dermonecrot...
Citation: BMC Microbiology 2001 1:33 -
An optimised recovery method for thermophilic Campylobacter from liver
The past three decades have witnessed the rise of Campylobacter enteritis in man from virtual obscurity to notoriety, with present isolation rates superseding those of other enteric pathogens such as Salmonella s...
Citation: BMC Microbiology 2001 1:32 -
A novel tetratricopeptide repeat (TPR) containing PP5 serine/threonine protein phosphatase in the malaria parasite, Plasmodium falciparum
The malarial parasite, Plasmodium falciparum (Pf), is responsible for nearly 2 million deaths worldwide. However, the mechanisms of cellular signaling in the parasite remain largely unknown. Recent discovery of a...
Citation: BMC Microbiology 2001 1:31 -
Analysis of HIV-1 drug resistant mutations by line probe assay and direct sequencing in a cohort of therapy naive HIV-1 infected Italian patients
The routine determination of drug resistance in newly HIV-1 infected individuals documents a potential increase in the transmission of drug-resistant variants. Plasma samples from twenty seven therapy naive HI...
Citation: BMC Microbiology 2001 1:30 -
RNA triphosphatase is essential in Schizosaccharomyces pombe and Candida albicans
The first two steps in the capping of cellular mRNAs are catalyzed by the enzymes RNA triphosphatase and RNA guanylyltransferase. Although structural and mechanistic differences between fungal and mammalian RN...
Citation: BMC Microbiology 2001 1:29 -
Development of dengue virus replicons expressing HIV-1 gp120 and other heterologous genes: a potential future tool for dual vaccination against dengue virus and HIV
Toward the goals of providing an additional vector to add to the armamentarium available to HIV vaccinologists and of creating a bivalent vaccine effective against dengue virus and HIV, we have attempted to cr...
Citation: BMC Microbiology 2001 1:28 -
Bacterial response to siderophore and quorum-sensing chemical signals in the seawater microbial community
Oceans are iron-deficient and nutrient-poor environments. These conditions impart limitations on our understanding of and our ability to identify microorganisms from the marine environment. However, less of kn...
Citation: BMC Microbiology 2001 1:27 -
Identification of two Mycobacterium tuberculosis H37Rv ORFs involved in resistance to killing by human macrophages
The ability of Mycobacterium tuberculosis to survive and replicate in macrophages is crucial for the mycobacterium's ability to infect the host and cause tuberculosis. To identify Mycobacterium tuberculosis genes...
Citation: BMC Microbiology 2001 1:26 -
Lactoferrin and free secretory component of human milk inhibit the adhesion of enteropathogenic Escherichia coli to HeLa cells
Diarrhoea caused by Escherichia coli is an important cause of infant morbidity and mortality in developing countries. Enteropathogenic Escherichia coli (EPEC) is considered one of the major causes of diarrhoea in...
Citation: BMC Microbiology 2001 1:25 -
Characterization of Norwalk virus GI specific monoclonal antibodies generated against Escherichia coli expressed capsid protein and the reactivity of two broadly reactive monoclonal antibodies generated against GII capsid towards GI recombinant fragments
Norwalk virus causes outbreaks of acute non-bacterial gastroenteritis in humans. The virus capsid is composed of a single 60 kDa protein. In a previous study, the capsid protein of recombinant Norwalk virus ge...
Citation: BMC Microbiology 2001 1:24 -
Small-scale analysis of exopolysaccharides from Streptococcus thermophilus grown in a semi-defined medium
Exopolysaccharides (EPSs) produced by lactic acid bacteria are important for the texture of fermented foods and have received a great deal of interest recently. However, the low production levels of EPSs in co...
Citation: BMC Microbiology 2001 1:23 -
The Yersinia YopE and YopH type III effector proteins enhance bacterial proliferation following contact with eukaryotic cells
Several bacterial pathogens express antihost factors that likely decrease both their maximal growth rate (due to metabolic costs) as well as their mortality rate (by neutralizing host defenses). The pathogenic...
Citation: BMC Microbiology 2001 1:22 -
Fluorescence of fungi in superficial and deep fungal infections
Fluorescence of many fungi is noted when H&E stained sections are examined under a fluorescent microscope. In theory, this phenomenon could aid in the diagnosis of cutaneous and disseminated fungal infections ...
Citation: BMC Microbiology 2001 1:21 -
Utilization of tmRNA sequences for bacterial identification
Ribosomal RNA molecules are widely used for phylogenetic and in situ identification of bacteria. Nevertheless, their use to distinguish microorganisms within a species is often restricted by the high degree of se...
Citation: BMC Microbiology 2001 1:20 -
amiA is a negative regulator of acetamidase expression in Mycobacterium smegmatis
The acetamidase of Mycobacterium smegmatis is a highly inducible enzyme. Expression of this enzyme is increased 100-fold when the substrate acetamide is present. The acetamidase gene is found immediately downstre...
Citation: BMC Microbiology 2001 1:19 -
Development of Dengue virus type 2 replicons capable of prolonged expression in host cells
As part of a program to develop a Dengue virus vaccine which avoids the deleterious effects of antibody dependent enhancement (ADE) of infection mediated by antibodies to Dengue virus structural proteins, we h...
Citation: BMC Microbiology 2001 1:18 -
In vivo involvement of polymorphonuclear neutrophils in Leishmania infantum infection
The role of lymphocytes in the specific defence against L. infantum has been well established, but the part played by polynuclear neutrophil (PN) cells in controlling visceral leishmaniasis was much less studied....
Citation: BMC Microbiology 2001 1:17 -
Monoclonal antibodies against the iron regulated outer membrane Proteins of Acinetobacter baumannii are bactericidal
Iron is an important nutrient required by all forms of life.In the case of human hosts,the free iron availability is 10-18M,which is far less than what is needed for the survival of the invading bacterial pathoge...
Citation: BMC Microbiology 2001 1:16 -
MtnK, methylthioribose kinase, is a starvation-induced protein in Bacillus subtilis
Methylthioadenosine, the main by-product of spermidine synthesis, is degraded in Bacillus subtilis as adenine and methylthioribose. The latter is an excellent sulfur source and the precursor of quorum-sensing sig...
Citation: BMC Microbiology 2001 1:15 -
Gastroenteritis outbreaks associated with Norwalk-like viruses and their investigation by nested RT-PCR
Norwalk-like viruses are the most common cause of gastroenteritis outbreaks and sporadic cases of vomiting and diarrhoea. In healthy individuals infection is often mild and short-lived but in debilitated patie...
Citation: BMC Microbiology 2001 1:14 -
Phenotyping of Campylobacter jejuni and Campylobacter coli by a quantitative antibiogram [MIC] typing scheme using Euclidean distances [QATED]
Enteropathogenic Campylobacter jejuni and C. coli are presently the most common cause of acute bacterial gastroenteritis in the developed world. An understanding of sources and means of transmission of Campylobac...
Citation: BMC Microbiology 2001 1:13 -
Evidence that the RNAseH activity of the duck hepatitis B virus is unable to act on exogenous substrates
The hepadnaviral reverse transcriptase can synthesize DNA on its native RNA template within viral cores but it is usually unable to synthesize DNA employing exogenous nucleic acids as a template. The mechanism...
Citation: BMC Microbiology 2001 1:12 -
Acquisition of tolerance against oxidative damage in Saccharomyces cerevisiae
Living cells constantly sense and adapt to redox shifts by the induction of genes whose products act to maintain the cellular redox environment. In the eukaryote Saccharomyces cerevisiae, while stationary cells p...
Citation: BMC Microbiology 2001 1:11 -
Low frequency of mutations in the core promoter and precore regions of hepatitis B virus in anti-HBe positive Brazilian carriers
Mutations in the core promoter and precore regions of the hepatitis B virus (HBV) genome, notably the double substitution (AGG to TGA) at nt positions 1762-1764 in the core promoter, and the precore stop codon...
Citation: BMC Microbiology 2001 1:10 -
Sub-inhibitory concentrations of vancomycin prevent quinolone-resistance in a penicillin-resistant isolate of Streptococcus pneumoniae
The continuous spread of penicillin-resistant pneumococci represents a permanent threat in the treatment of pneumococcal infections, especially when strains show additional resistance to quinolones. The main o...
Citation: BMC Microbiology 2001 1:9 -
Alteration in expression of the rat mitochondrial ATPase 6 gene during Pneumocystis carinii infection
Pneumocystis carinii causes pneumonia in immunocompromised patients with a high morbidity and mortality rate, but the interaction between this organism and the host cell is not well understood. The purpose of thi...
Citation: BMC Microbiology 2001 1:8 -
Site-specific mutations of FtsZ - effects on GTPase and in vitro assembly
FtsZ, the major cytoskeletal protein in bacterial cytokinesis, assembles in vitro into protofilaments, which can further associate into sheets, bundles or tubes. We have constructed 16 site-directed mutants of E....
Citation: BMC Microbiology 2001 1:7 -
A glutamine-amidotransferase-like protein modulates FixT anti-kinase activity in Sinorhizobium meliloti
Nitrogen fixation gene expression in Sinorhizobium meliloti, the alfalfa symbiont, depends on a cascade of regulation that involves both positive and negative control. On top of the cascade, the two-component reg...
Citation: BMC Microbiology 2001 1:6 -
Phylogenetic analysis of methanogens from the bovine rumen
Interest in methanogens from ruminants has resulted from the role of methane in global warming and from the fact that cattle typically lose 6 % of ingested energy as methane. Several species of methanogens hav...
Citation: BMC Microbiology 2001 1:5 -
Envelope structure of Synechococcus sp. WH8113, a nonflagellated swimming cyanobacterium
Many bacteria swim by rotating helical flagellar filaments [1]. Waterbury et al. [15] discovered an exception, strains of the cyanobacterium Synechococcus that swim without flagella or visible changes in shape. O...
Citation: BMC Microbiology 2001 1:4 -
Analysis of stress- and host cell-induced expression of the Mycobacterium tuberculosis inorganic pyrophosphatase
The gene encoding the inorganic pyrophosphatase (PPase) of the intracellular pathogen Legionella pneumophila is induced during intracellular infection, but is constitutively expressed in Eschericia coli. The caus...
Citation: BMC Microbiology 2001 1:3 -
A tandem repeats database for bacterial genomes: application to the genotyping of Yersinia pestis and Bacillus anthracis
Some pathogenic bacteria are genetically very homogeneous, making strain discrimination difficult. In the last few years, tandem repeats have been increasingly recognized as markers of choice for genotyping a ...
Citation: BMC Microbiology 2001 1:2 -
The viral transmembrane superfamily: possible divergence of Arenavirus and Filovirus glycoproteins from a common RNA virus ancestor
Recent studies of viral entry proteins from influenza, measles, human immunodeficiency virus, type 1 (HIV-1), and Ebola virus have shown, first with molecular modeling, and then X-ray crystallographic or other...
Citation: BMC Microbiology 2001 1:1
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