Holland RE. Some infectious causes of diarrhea in young farm animals. Clin Microbiol Rev. 1990;3(4):345.
Article
CAS
PubMed
PubMed Central
Google Scholar
Alexa P, Hamřík J, Konstantinová L, Šrámková-Zajacová Z. Experimental infection of weaned piglets with enterotoxigenic Escherichia coli O149: F4. Acta Vet Brno. 2011;80(4):337–341.
Francis DH. Enterotoxigenic Escherichia coli infection in pigs and its diagnosis. J Swine Health Prod. 2002;10(4):171–5.
Google Scholar
Moxley RA, Duhamel GE. Comparative pathology of bacterial enteric diseases of swine. In: Mechanisms in the Pathogenesis of Enteric Diseases 2. edn. New York: Springer; 199983–101.
Nagy B, Fekete PZ. Enterotoxigenic Escherichia coli (ETEC) in farm animals. Vet Res. 1999;30(2-3):259–84.
CAS
PubMed
Google Scholar
Berberov EM, Zhou Y, Francis DH, Scott MA, Kachman SD, Moxley RA. Relative importance of heat-labile enterotoxin in the causation of severe diarrheal disease in the gnotobiotic piglet model by a strain of enterotoxigenic Escherichia coli that produces multiple enterotoxins. Infect Immun. 2004;72(7):3914–24.
Article
CAS
PubMed
PubMed Central
Google Scholar
Erume J, Berberov EM, Kachman SD, Scott MA, Zhou Y, Francis DH, Moxley RA. Comparison of the contributions of heat-labile enterotoxin and heat-stable enterotoxin b to the virulence of enterotoxigenic Escherichia coli in F4ac receptor-positive young pigs. Infect Immun. 2008;76(7):3141–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Fairbrother JM, Nadeau É, Gyles CL. Escherichia coli in postweaning diarrhea in pigs: an update on bacterial types, pathogenesis, and prevention strategies. Anim Health Res Rev. 2005;6(01):17–39.
Article
CAS
PubMed
Google Scholar
Madec F, Bridoux N, Bounaix S, Cariolet R, Duval-Iflah Y, Hampson DJ, Jestin A. Experimental models of porcine post-weaning colibacillosis and their relationship to post-weaning diarrhoea and digestive disorders as encountered in the field. Vet Microbiol. 2000;72(3):295–310.
Article
CAS
PubMed
Google Scholar
Cutler SA, Lonergan SM, Cornick N, Johnson AK, Stahl CH. Dietary inclusion of colicin e1 is effective in preventing postweaning diarrhea caused by F18-positive Escherichia coli in pigs. Antimicrob Agents Chemother. 2007;51(11):3830–5.
Article
CAS
PubMed
PubMed Central
Google Scholar
Rossi L, Vagni S, Polidori C, Alborali GL, Baldi A, Dell’Orto V. Experimental induction of Escherichia coli diarrhoea in weaned piglets. Open J Vet Med. 2012;2:1.
Article
Google Scholar
Jones G, Rutter J. Role of the K88 antigen in the pathogenesis of neonatal diarrhea caused by Escherichia coli in piglets. Infect Immun. 1972;6(6):918–27.
CAS
PubMed
PubMed Central
Google Scholar
Gill DM, Richardson SH. Adenosine diphosphate-ribosylation of adenylate cyclase catalyzed by heat-labile enterotoxin of Escherichia coli: comparison with cholera toxin. J Infect Dis. 1980;141(1):64–70.
Article
CAS
PubMed
Google Scholar
Huott PA, Liu W, McRoberts JA, Giannella RA, Dharmsathaphorn K. Mechanism of action of Escherichia coli heat stable enterotoxin in a human colonic cell line. J Clin Invest. 1988;82(2):514.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kennedy D, Greenberg R, Dunn J, Abernathy R, Ryerse J, Guerrant R. Effects of Escherichia coli heat-stable enterotoxin STb on intestines of mice, rats, rabbits, and piglets. Infect Immun. 1984;46(3):639–43.
CAS
PubMed
PubMed Central
Google Scholar
Do TN, Wilkie I, Driesen S, Fahy V, Trott DJ. Pathogenicity of Vietnamese enterotoxigenic Escherichia coli strains in colostrum-deprived one-day-old piglets. Vet Pathol Online. 2006b;43(2):150-160.
Nagy B, Fekete PZ. Enterotoxigenic Escherichia coli in veterinary medicine. International Journal of Medical Microbiology. 2005;295(6):443–54.
Moseley S, Dougan G, Schneider R, Moon H. Cloning of chromosomal DNA encoding the F41 adhesin of enterotoxigenic Escherichia coli and genetic homology between adhesins F41 and K88. J Bacteriol. 1986;167(3):799–804.
CAS
PubMed
PubMed Central
Google Scholar
Niewerth U, Frey A, Voss T, Le Bouguénec C, Baljer G, Franke S, Schmidt MA. The AIDA autotransporter system is associated with F18 and stx2e in Escherichia coli isolates from pigs diagnosed with edema disease and postweaning diarrhea. Clin Diagn Lab Immunol. 2001;8(1):143–9.
CAS
PubMed
PubMed Central
Google Scholar
Rippinger P, Bertschinger H, Imberechts H, Nagy B, Sorg I, Stamm M, Wild P, Wittig W. Designations F18ab and F18ac for the related fimbrial types F107, 2134P and 8813 of Escherichia coli isolated from porcine postweaning diarrhoea and from oedema disease. Vet Microbiol. 1995;45(4):281–95.
Article
CAS
PubMed
Google Scholar
Ngeleka M, Pritchard J, Appleyard G, Middleton DM, Fairbrother JM. Isolation and association of Escherichia coli AIDA-I/STb, rather than EAST1 pathotype, with diarrhea in piglets and antibiotic sensitivity of isolates. J Vet Diagn Invest. 2003;15(3):242–52.
Article
PubMed
Google Scholar
Leclerc S, Boerlin P, Gyles C, Dubreuil JD, Mourez M, Fairbrother JM, Harel J. Paa, originally identified in attaching and effacing Escherichia coli, is also associated with enterotoxigenic E. coli. Res Microbiol. 2007;158(1):97–104.
Article
CAS
PubMed
Google Scholar
Byun J, Jung B, Kim H, FairbrotheR J, Lee M, Lee W. O-serogroups, virulence genes of pathogenic Escherichia coli and Pulsed-field gel electrophoresis (PFGE) patterns of O149 isolates from diarrhoeic piglets in Korea. Vet Med. 2013;58(9):468–76.
Google Scholar
Guevara C, Luiz W, Sierra A, Cruz C, Qadri F, Kaushik R, Ferreira L, Gomez-Duarte O. Enterotoxigenic Escherichia coli CS21 pilus contributes to adhesion to intestinal cells and to pathogenesis under in vivo conditions. Microbiology. 2013;159(8):1725–35.
Article
CAS
PubMed
PubMed Central
Google Scholar
Madoroba E, Van Driessche E, De Greve H, Mast J, Ncube I, Read J, Beeckmans S. Prevalence of enterotoxigenic Escherichia coli virulence genes from scouring piglets in Zimbabwe. Tropl Anim Health Prod. 2009;41(7):1539–47.
Article
Google Scholar
Burgess M, Bywater R, Cowley C, Mullan N, Newsome P. Biological evaluation of a methanol-soluble, heat-stable Escherichia coli enterotoxin in infant mice, pigs, rabbits, and calves. Infect Immun. 1978;21(2):526–31.
CAS
PubMed
PubMed Central
Google Scholar
Pickett CL, Twiddy EM, Belisle BW, Holmes RK. Cloning of genes that encode a new heat-labile enterotoxin of Escherichia coli. J Bacteriol. 1986;165(2):348–52.
CAS
PubMed
PubMed Central
Google Scholar
Jobling MG, Holmes RK. Type II heat-labile enterotoxins from 50 diverse Escherichia coli isolates belong almost exclusively to the LT-IIc family and may be prophage encoded. PLoS One. 2012;7(1):e29898.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ruan X, Crupper SS, Schultz BD, Robertson DC, Zhang W. Escherichia coli expressing EAST1 toxin did not cause an increase of cAMP or cGMP levels in cells, and no diarrhea in 5-day old gnotobiotic pigs. PLoS One. 2012;7(8):e43203.
Article
CAS
PubMed
PubMed Central
Google Scholar
Morgan R, Isaacson R, Moon H, Brinton C, To C. Immunization of suckling pigs against enterotoxigenic Escherichia coli-induced diarrheal disease by vaccinating dams with purified 987 or K99 pili: protection correlates with pilus homology of vaccine and challenge. Infect Immun. 1978;22(3):771–7.
CAS
PubMed
PubMed Central
Google Scholar
Nagy B, Moon H, Isaacson R, To C, Brinton C. Immunization of suckling pigs against enteric enterotoxigenic Escherichia coli infection by vaccinating dams with purified pili. Infect Immun. 1978;21(1):269–74.
CAS
PubMed
PubMed Central
Google Scholar
Ikwap K, Jacobson M, LUndeheim N, Owiny D, Nasinyama G, Fellström C, Erume J. Characterization of pig production in Gulu and Soroti districts in northern and eastern Uganda. Livest Res Rural Dev. 2014;26:74.
Google Scholar
Ikwap K, Erume J, Owiny DO, Nasinyama GW, Melin L, Bengtsson B, Lundeheim N, Fellström C, Jacobson M. Salmonella species in piglets and weaners from Uganda: Prevalence, antimicrobial resistance and herd-level risk factors. Prev Vet Med. 2014a;115(1):39-47.
PEN. Pathogenic Escherichia coli Network: methods for detection and molecular characterisation of pathogenic Escherichia coli. Co-ordination Action Food-CT-2006-036256. Dublin 15, Ireland: Teagasc, Ashtown Food Research Centre; 2006.
AASP: On Farm Euthanasia of Swine: Options for the Producer. American Association of Swine Practitioners 2001, National Pork Producers Council in cooperation with the National Pork Board (Des Moines, Iowa, 4 p. ISBN: 1-892769-10-7). http://www.aasp.org/aasv/euthanasia.pdf. Accessed 3 Aug 2016.
Brown HS. Hematoxylin and eosin (The routine stain). St. Louis, Missouri, USA: SIGMA-ALDRICH; 2002.
Costa MM, Drescher G, Maboni F, Weber SS, Schrank A, Vainstein MH, Schrank IS, Vargas AC. Virulence factors, antimicrobial resistance, and plasmid content of Escherichia coli isolated in swine commercial farms. Arq Bras Med Vet Zootecnia. 2010;62(1):30–6.
Article
Google Scholar
Toledo A, Gómez D, Cruz C, Carreón R, López J, Giono S, Castro AM. Prevalence of virulence genes in Escherichia coli strains isolated from piglets in the suckling and weaning period in Mexico. J Med Microbiol. 2012;61(1):148–56.
Article
CAS
PubMed
Google Scholar
Weary DM, Fraser D. Vocal response of piglets to weaning: effect of piglet age. Appl Anim Behav Sci. 1997;54(2):153–60.
Article
Google Scholar
Hampson DJ. Post-weaning E. coli diarrhea in pigs. In: Gyles CL, editor. Escherichia coli in domestic animals and humans. Wallingford: CAB International; 1994. p. 171–91.
Google Scholar
Moon HW, Bunn TO. Vaccines for preventing enterotoxigenic Escherichia coli infections in farm animals. Vaccine. 1993;11(2):213–20.
Article
CAS
PubMed
Google Scholar
Wittig W, Fabricius C. Escherichia coli types isolated from porcine E. coli infections in Saxony from 1963 to 1990. Zentralbl Bakteriol. 1992;277(3):389–402.
Article
CAS
PubMed
Google Scholar
Zhang W, Zhao M, Ruesch L, Omot A, Francis D. Prevalence of virulence genes in Escherichia coli strains recently isolated from young pigs with diarrhea in the US. Vet Microbiol. 2007;123(1):145–52.
Article
CAS
PubMed
Google Scholar
Žutić J, Ašanin J, Mišić D, Jakić-Dimić D, Milić N, Ašanin R, Stojanović D, Žutić M. Isolation of ETEC strains from piglets with diarrhea in the neonatal period and their typization based on somatic and fimbrial antigens. Acta Vet Brno. 2010;60(5-6):497–506.
Article
Google Scholar
Garabal J, Gonzalez E, Vazquez F, Blanco J, Blanco M, Blanco J. Serogroups of Escherichia coli isolated from piglets in Spain. Vet Microbiol. 1996;48(1):113–23.
Article
CAS
PubMed
Google Scholar
Frydendahl K. Prevalence of serogroups and virulence genes in Escherichia coli associated with postweaning diarrhoea and edema disease in pigs and a comparison of diagnostic approaches. Vet Microbiol. 2002;85(2):169–82.
Article
CAS
PubMed
Google Scholar
Okello E, Moonens K, Erume J, De Greve H. Enterotoxigenic Escherichia coli strains are highly prevalent in Ugandan piggeries but disease outbreaks are masked by antibiotic prophylaxis. Tropical animal health and production. 2015;47(1):117–22.
Kim YJ, Kim JH, Hur J, Lee JH. Isolation of Escherichia coli from piglets in South Korea with diarrhea and characteristics of the virulence genes. Can J Vet Res. 2010;74(1):59.
CAS
PubMed
PubMed Central
Google Scholar
Alexander T. Neonatal diarrhoea in pigs. In: Gyle CL, editor. E. coli in domestic animals and humans. Willingfrod: CAB International; 1994. p. 151–70.
Google Scholar
Laarmann S, Schmidt MA. The Escherichia coli AIDA autotransporter adhesin recognizes an integral membrane glycoprotein as receptor. Microbiology. 2003;149(7):1871–82.
Article
CAS
PubMed
Google Scholar
Osek J, Truszczyński M. Occurrence of fimbriae and enterotoxins in Escherichia coli strains isolated from piglets in poland. Comp Immunol Microbiol Infect Dis. 1992;15(4):285–92.
Article
CAS
PubMed
Google Scholar
Vu-Khac H, Holoda E, Pilipcinec E, Blanco M, Blanco J, Dahbi G, Mora A, López C, González E, Blanco J. Serotypes, virulence genes, intimin types and PFGE profiles of Escherichia coli isolated from piglets with diarrhoea in Slovakia. Vet J. 2007;174(1):176–87.
Article
CAS
PubMed
Google Scholar
Choi C, Kwon D, Chae C. Prevalence of the enteroaggregative Escherichia coli heat-stable enterotoxin 1 gene and its relationship with fimbrial and enterotoxin genes in E. coli isolated from diarrheic piglets. J Vet Diagn Invest. 2001;13(1):26–9.
Article
CAS
PubMed
Google Scholar
Erume J, Wijemanne P, Berberov EM, Kachman SD, Oestmann DJ, Francis DH, Moxley RA. Inverse relationship between heat stable enterotoxin-b induced fluid accumulation and adherence of F4ac-positive enterotoxigenic Escherichia coli in ligated jejunal loops of F4ab/ac fimbria receptor-positive swine. Vet Microbiol. 2013;161(3):315–24.
Article
CAS
PubMed
Google Scholar
Pass M, Odedra R, Batt R. Multiplex PCRs for Identification of Escherichia coli Virulence Genes. J Clin Microbiol. 2000;38(5):2001–4.
CAS
PubMed
PubMed Central
Google Scholar
Larsson J, Aspán A, Lindberg R, Grandon R, Båverud V, Fall N, Jacobson M. Pathological and bacteriological characterization of neonatal porcine diarrhoea of uncertain aetiology. J Med Microbiol. 2015;64(8):916–26.
Article
CAS
PubMed
Google Scholar
Ojeniyi B, Ahrens P, Meyling A. Detection of fimbrial and toxin genes in Escherichia coli and their prevalence in piglets with diarrhoea. The application of colony hybridization assay, polymerase chain reaction and phenotypic assays. J Vet Med B. 1994;41(1‐10):49–59.
Article
CAS
Google Scholar
Franck SM, Bosworth BT, Moon HW. Multiplex PCR for enterotoxigenic, attaching and effacing, and Shiga toxin-producing Escherichia coli strains from calves. J Clin Microbiol. 1998;36(6):1795–7.
CAS
PubMed
PubMed Central
Google Scholar
Bosworth BT, Dean-Nystrom EA, Casey TA, Neibergs HL. Differentiation of F18ab + from F18ac + Escherichia coli by single-strand conformational polymorphism analysis of the major fimbrial subunit gene (fedA). Clin Diagn Lab Immunol. 1998;5(3):299–302.
CAS
PubMed
PubMed Central
Google Scholar