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Erratum to: Exploring the contribution of efflux on the resistance to fluoroquinolones in clinical isolates of Staphylococcus aureus

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The original article was published in BMC Microbiology 2011 11:241

After the publication of our study [1], we became aware that the mutations in the quinolone resistance-determining region (QRDR) of the gene grlA were incorrectly described for some of the Staphylococcus aureus clinical isolates studied in this work. In particular, isolates SM1, SM10, SM14, SM17, SM25, SM27, SM43, SM46, SM47 and SM48 carry the GrlA double mutation S80Y/E84G; isolate SM52 carries the GrlA mutation S80Y; isolates SM3 and SM5 carry the GrlA double mutation S80F/E84G. The correct data can be found in Table 1.

Table 1 Genotypic and phenotypic characterization of S. aureus clinical isolates

All clinical isolates included in this study were selected upon a ciprofloxacin resistance phenotype and all the 25 representative isolates screened for mutations conferring fluoroquinolone resistance carried QRDR mutations in both grlA and gyrA genes. All the mutations found have been described in literature as associated with fluoroquinolone resistance in S. aureus clinical isolates [2]. As stated previously in our study, the majority of the isolates presented a double mutation in GrlA together with a single mutation in GyrA. Eleven isolates carried the GrlA and GyrA mutations S80Y/E84G and S84L, respectively; three isolates carried mutations GrlA S80F/E84K and GyrA S84L and two isolates carried mutations GrlA S80F/E84G and GyrA S84L.The remaining nine isolates carried a single mutation in both genes, in three distinct arrangements (Table 1).

Despite this correction in the QRDR mutations carried by some of the isolates studied, the main findings of our study are not altered. In particular, our data show the potential role played by efflux systems in the development of resistance to fluoroquinolones in clinical isolates of S. aureus, independently of the mutations occurring in the target genes.

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References

  1. 1.

    Costa SS, Falcão C, Viveiros M, Machado D, Martins M, Melo-Cristino J, Amaral L, Couto I: Exploring the contribution of efflux on the resistance to fluoroquinolones in clinical isolates of Staphylococcus aureus. BMC Microbiol. 2011, 11: 241-10.1186/1471-2180-11-241.

  2. 2.

    Hooper DC: Mechanisms of fluoroquinolone resistance. Drug Resist Updat. 1999, 2: 38-55. 10.1054/drup.1998.0068.

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Correspondence to Isabel Couto.

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The online version of the original article can be found at 10.1186/1471-2180-11-241

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