Featured review: Structure, Genetics and Worldwide Spread of NDM-1: a threat to public health

The emergence of carbapenemase producing bacteria, especially New Delhi metallo-β-lactamase (NDM-1) and its variants, worldwide, has raised a major public health concern. NDM-1 hydrolyses a wide range of β-lactam antibiotics, including carbapenems, which are the last resort of antibiotics for the treatment of infections caused by resistant strain of bacteria.This review provides a comprehensive view of structural differences among NDM-1 variants, which are a driving force behind their spread across the globe. 

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Featured article: Dominant bacterial phyla in caves and their predicted functional roles in C and N cycle

Bacteria constitute the major portion of the cave biodiversity and play a key role in maintaining the cave ecosystem. Bacteria present in caves often survive by modifying their metabolic pathway or other mechanism. The present study utilised Illumina sequencing along with bioinformatics analysis to reveal the essential ecological role of cave bacterial communities in India. These results will be useful in documenting the biospeleology of this region and the systematic understanding of bacterial communities in natural sediment environments as well.

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Aims and scope

BMC Microbiology is an open access, peer-reviewed journal that considers articles on analytical and functional studies of prokaryotic and eukaryotic microorganisms, viruses and small parasites, as well as host and therapeutic responses to them and their interaction with the environment.


  • Alexandros Houssein, BioMed Central

Section Editors

  • Stéphane Aymerich, INRA
  • Ralf Heermann, Ludwig-Maximilians-Universitaet
  • Igor Mokrousov, St. Petersburg Pasteur Institute
  • Hirotada Mori, Nara Institute of Science and Technology
  • David Nelson, University of Rhode Island
  • Marco Ventura, University of Parma
  • Raffaele Zarrilli, Università di Napoli Federico II
  • Jizhong Zhou, University of Oklahoma