Table 4 Genetic variations associated with cefuroxime, amoxicillin-clavulanate, ciprofloxacin/levofloxacin, and trimethoprim-sulfamethoxazole non-susceptibility in non-typeable Haemophilus influenzae isolates

Cefuroxime

18

8

 HI_1132 (ftsI)

  1070G > A (Ser357Asn)

6

7

0.030

0.805 (0.087)

76.9%

69.2%

0.008

  1594A > T (Thr532Ser)

1

4

0.020

0.910 (0.066)

80.0%

85.7%

0.005

  1669 T > C (Tyr557His)

1

5

0.004

0.946 (0.050)

83.3%

90.0%

0.001

 HI_1655 (lpoA)

  453G > C (Met151Ile)

0

3

0.022

0.891 (0.071)

100.0%

82.6%

0.030

Amoxicillin-clavulanate

22

4

 HI_0032 (mrdA)

  1552G > A (Ala518Thr)

6

4

0.014

0.750 (0.101)

50.0%

100.0%

0.035

 HI_0197 (mepA)

  82C > A (Gln28Lys)

4

3

0.047

0.767 (0.125)

57.1%

94.7%

0.040

 HI_0364 (pbpG)

  674G > T (Arg225Leu)

6

4

0.014

0.859 (0.073)

70.0%

81.2%

0.002

Ciprofloxacin / Levofloxacin

11

15

 HI_1264 (gyrA)

  251C > T (Ser84Phe)

4

13

0.014

0.752 (0.103)

86.7%

63.6%

0.031

  263A > G (Asp88Gly)

0

7

0.010

0.733 (0.098)

46.7%

100.0%

0.046

  1299G > T (Glu433Asp)

1

9

0.014

0.755 (0.097)

60.0%

90.9%

0.029

  1414A > G (Ile472Val)

1

10

0.005

0.788 (0.092)

66.7%

90.9%

0.014

  2220 T > A (Asp740Glu)

1

8

0.036

0.721 (0.101)

53.3%

90.9%

0.058

 HI_0567 (gyrB)

  1817C > T (Ala606Val)

5

13

0.038

0.706 (0.109)

86.7%

54.5%

0.078

  2174C > T (Ala725Val)

1

9

0.014

0.755 (0.097)

60.0%

90.9%

0.029

 HI_1529 (parC)

  59A > G (Lys20Arg)

0

11

 < 0.001

0.867 (0.074)

73.3%

100.0%

0.002

  251G > T (Ser84Ile)

1

11

0.002

0.821 (0.087)

73.3%

90.9%

0.006

  1601G > A (Ser534Asn)

0

6

0.024

0.700 (0.102)

40.0%

100.0%

0.087

 HI_1528 (parE)

  434G > A (Ser145Asn)

0

8

0.007

0.767 (0.094)

53.3%

100.0%

0.022

 parC-parE intergenic region

  n.1600250A > C

0

11

 < 0.001

0.867 (0.074)

73.3%

100.0%

0.002

Trimethoprim-sulfamethoxazole

6

20

 HI_0899 (folA)

  38A > G (Asn13Ser)

1

19

 < 0.001

0.954 (0.047)

100.0%

83.3%

 < 0.001

  63G > A (Met21Ile)

0

11

0.024

0.585 (0.114)

100.0%

40.0%

0.467

  200T > C (Leu67Pro)

0

13

0.015

0.654 (0.112)

100.0%

46.2%

0.182

  250A > T (Asn84Tyr)

0

11

0.024

0.585 (0.114)

100.0%

40.0%

0.467

  283A > C (Ile95Leu)

1

17

0.004

0.795 (0.112)

100.0%

62.5%

0.018

  319A > C (Lys107Gln)

0

16

 < 0.001

0.775 (0.106)

100.0%

60.0%

0.020