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Table 2 Antifungal susceptibilities of 65 clinical isolates of Candida spp. to amphotericin B (AMB), fluconazole (FLC), and itraconazole (ITC) by the CLSI reference broth microdilution method.

From: Growth inhibition and ultrastructural alterations induced by Δ24(25)-sterol methyltransferase inhibitors in Candida spp. isolates, including non-albicans organisms

Antifungal

Species (no. of isolates)

Concentration (μg.ml-1)

Susceptibility no. isolates (%)

  

range of the MICs

+MIC50

+MIC90

S

SDD

R

AMB

All species (65)

≤ 0.007 – 1

0.06

0.12

65 (100)

-

 
 

Candida albicans (21)

≤ 0.007 – 0.5

0.06

0.12

21 (100)

-

 
 

Candida parapsilosis (19)

0.015 – 0.5

0.03

0.12

19 (100)

-

 
 

Candida tropicalis (14)

0.015 – 1

0.06

0.25

14 (100)

-

 
 

Candida glabrata (2)

0.015–0.5

0.12

0.25

2 (100)

-

 
 

Candida krusei (1)

0.25 – 0.5

0.25

0.5

1 (100)

-

 
 

Candida lusitaneae (1)

0.06 – 0.12

0.06

0.12

1 (100)

-

 
 

Candida guilliermondii (3)

0.015 – 1

0.015

0.06

3 (100)

-

 
 

Candida zeylanoides (1)

0.06 – 0.12

0.06

0.12

1 (100)

-

 
 

Candida rugosa (1)

0.03 – 0.12

0.03

0.12

1 (100)

-

 
 

Candida dubliniensis (1)

0.12 – 0.25

0.12

0.25

1 (100)

-

 
 

Candida lipolytica (1)

0.12 – 0.25

0.12

0.25

1 (100)

-

 

FLC

All species (65)

≤ 0.25 – > 128*

0.5

1

60 (92.31)

2 (3.07)

3 (4.62)

 

Candida albicans (21)

≤ 0.25 – > 128*

0.25

4

21 (100)

  
 

Candida parapsilosis (19)

≤ 0.25 – > 128*

0.5

0.5

19 (100)

  
 

Candida tropicalis (14)

≤ 0.25 – > 128*

0.5

4.5

12 (85.71)

 

2 (14.29)

 

Candida glabrata (2)

≤ 0.25 – > 128*

4

64

2 (100)

  
 

Candida krusei (1)

16 – > 128

16

> 128

  

1 (100)

 

Candida lusitaneae (1)

0.5 – 1

0.5

1

1 (100)

  
 

Candida guilliermondii (3)

0.12 – 16

4

4

2 (66.67)

1 (33.33)

 
 

Candida zeylanoides (1)

4 – 16

4

16

 

1 (100)

 
 

Candida rugosa (1)

0.5

0.5

0.5

1 (100)

  
 

Candida dubliniensis (1)

≤ 0.25 – 0.5

≤ 0.25

0.5

1 (100)

  
 

Candida lipolytica (1)

0.5 – 1

0.5

1

1 (100)

  

ITC

All species (65)

≤ 0.03 – > 16**

≤ 0.03

0.12

49 (75.38)

10 (15.38)

6 (9.23)

 

Candida albicans (21)

≤ 0.03 – > 16**

≤ 0.03

≤ 0.03

17 (80.95)

3 (14.28)

1 (4.76)

 

Candida parapsilosis (19)

≤ 0.03 – > 16**

≤ 0.03

≤ 0.03

18 (94.74)

1 (5.26)

 
 

Candida tropicalis (14)

≤ 0.03 – > 16**

≤ 0.03

1.25

9 (64.28)

2 (14.28)

3 (21.43)

 

Candida glabrata (2)

≤ 0.03 – 4

0.5

2

 

1 (50)

1 (50)

 

Candida krusei (1)

0.12 – 2

0.5

2

  

1 (100)

 

Candida lusitaneae (1)

≤ 0.03 – 0.12

≤ 0.03

0.12

1 (100)

  
 

Candida guilliermondii (3)

0.06 – 0.5

0.12

0.25

1 (33.33)

2 (66.66)

 
 

Candida zeylanoides (1)

0.06 – 0.12

0.06

0.12

1 (100)

  
 

Candida rugosa (1)

≤ 0.03

≤ 0.03

≤ 0.03

1 (100)

  
 

Candida dubliniensis (1)

0.06 – 0.12

0.06

0.12

1 (100)

  
 

Candida lipolytica (1)

0.25 – 0.5

0.25

0.5

 

1 (100)

 
  1. -Not determinate; +MIC results are medians; *Trailing effect to FLC [C. albicans (9), C. tropicalis (4), C. parapsilosis (3) and one C. glabrata(1)]; **Trailing effect to ITC [C. albicans (6), C. tropicalis (4) and C. parapsilosis (1)].
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BMC Microbiology

ISSN: 1471-2180

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