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Fig. 4 | BMC Microbiology

Fig. 4

From: Pretreatment with an antibiotics cocktail enhances the protective effect of probiotics by regulating SCFA metabolism and Th1/Th2/Th17 cell immune responses

Fig. 4

CBM reversed gut dysbiosis and SCFA metabolism after pretreatment with Abx. (A) The alpha-diversity in the Abx pretreated colitis with or without CBM intervention. (B) Unweighted UniFrac based PCoA analysis among groups. (C) The top 10 dominant bacteria taxa in the indicated groups at the level of phylum, order, family, and genus. (D) Heatmap of genus taxa with a relative abundance greater than 1% in the indicated group. (E) The up-regulated species in the Abx pretreated colitis with CBM intervention. (F) The down-regulated species in the Abx pretreated colitis with CBM intervention. (G) Fecal SCFA concentration among groups. These results are expressed as mean ± SEM. *P < 0.05, **P < 0.01, and ***P < 0.001 compared to the Abx + DSS group. CBM, Clostridium butirycum Miyairi588; DSS, dextran sodium sulfate; Abx, antibiotic cocktail; Abx + DSS, DSS-induced colitis model with Abx pretreatment; Abx + DSS + CBM, colitis mice treated with CBM combined with Abx pretreatment; and SCFA, short chain fatty acid

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BMC Microbiology

ISSN: 1471-2180

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