Skip to main content
Fig. 3 | BMC Microbiology

Fig. 3

From: Pretreatment with an antibiotics cocktail enhances the protective effect of probiotics by regulating SCFA metabolism and Th1/Th2/Th17 cell immune responses

Fig. 3

CBM restored the gut barrier damage and Abx pretreatment enhanced the efficacy. Zonula occludens (ZO) -1 (A), Occludin (B), mucin2 (MUC2)(C), and Relmβ (D) mRNA levels in the indicated groups. Representative ZO-1 (E), OCCLUDIN (F), CLAUDIN1 (G), and MUC2 (H) images, and the related immunohistochemical scores (I-L; 10× magnification large, 40× magnification small; scale bar – 200 μm) were presented. These results are expressed as mean ± SEM, n = 6. *P < 0.05, **P < 0.01, and ***P < 0.001 were compared to the DSS + CBM group. CBM, Clostridium butirycum Miyairi588; ZO, Zonula occludens; MUC2, mucin2; DSS, dextran sodium sulfate; Abx, antibiotic cocktail; DSS + CBM, CBM oral gavage treated colitis mice; and Abx + DSS + CBM, colitis mice treated with CBM combined with Abx pretreatment

Back to article page

BMC Microbiology

ISSN: 1471-2180

Contact us