Table 2 The molecular docking study between ligands and the E. coli cell proteins

AcrB

Ciprofloxacin

-4.151

GLN⁸⁹, THR⁹¹

2

Fosfomycin

-4.964

SER⁷⁹, GLU⁸²⁶

2

Enterobactin

-6.565

SER⁷⁹, THR⁹¹, PHE⁶¹⁷, GLU⁶⁸³, ASN⁷¹⁹, GLU⁸¹⁷, GLU⁸²⁶

8

TolC

Ciprofloxacin

-4.113

ASN⁵⁸, GLN²⁷³

2

Fosfomycin

-4.917

ASP⁵⁶

1

Enterobactin

-6.308

GLN²⁷³ (A), GLN²⁷³ (C), GLY²⁷¹

3

FepA

Fe⁺³-enterobactin

-5.585

ARG²⁸³

1

Fe⁺³-enterobactin -Ciprofloxacin

-6.3

ARG²⁸³, PHE ³³⁷

2

Fe⁺³-enterobactin -Fosfomycin

-5.605

ARG²⁸³

1

ARG²⁸³

FepB

Fe⁺³-enterobactin

-4.388

ASN⁷⁷, THR⁷⁴

2

PHE³⁰⁰

Fe⁺³-enterobactin -Ciprofloxacin

-6.789

ARG⁸⁷

1

LYS²⁷⁰

Fe⁺³-enterobactin -Fosfomycin

-5.986

ASN⁷⁷, ARG⁷⁸, THR²⁰⁰

3

PHE³⁰⁰

ARG⁷⁸

FepC

Fe⁺³-enterobactin

-7.09

TRP⁶⁵

1

TRP⁶⁵

Fe⁺³-enterobactin -Ciprofloxacin

-7.120

TRP⁶⁵, LEU²⁶, THR⁵²

3

TRP⁶⁵

Fe⁺³-enterobactin -Fosfomycin

-7.675

VAL²⁸

1

FepD

Fe⁺³-enterobactin

-6.217

GLN¹⁷⁹, SER¹⁸⁷, ASN¹⁹²

4

Fe⁺³-enterobactin -Ciprofloxacin

-6.810

ASN 192, THR 195

2

Fe⁺³-enterobactin -Fosfomycin

-8.016

SER¹⁰², PHE¹⁸², TRP¹⁸³

3

FepG

Fe⁺³-enterobactin

-5.318

GLU¹⁷²

PHE¹¹¹

Fe⁺³-enterobactin -Ciprofloxacin

-6.360

No Bonds

Fe⁺³-enterobactin -Fosfomycin

-6.3136

THR¹⁷³, ALA¹⁰⁷, LYS¹⁶⁸

LYS¹⁶⁸

DNA gyrase

Ciprofloxacin

-6.264

SER¹²⁹, THR¹⁷³

2

Fe⁺³-enterobactin -Ciprofloxacin

-8.597

GLU⁵⁰, ASP⁵⁷

3

MurA

Fosfomycin

-3.756

ASP²¹¹

2

Fe⁺³-enterobactin -Fosfomycin

-5.481

ASP²⁶⁰, ASP²⁵⁷, ARG²¹², ASP²¹¹

7

ARG²¹²