Outbreak of colistin and carbapenem-resistant Klebsiella pneumoniae ST16 co-producing NDM-1 and OXA-48 isolates in an Iranian hospital

Table 2 Microbiological and genomic characteristics of the Col-CRKP strains

Patients	Isolates	String test	Capsular serotype	Virulence genes	MLST	Resistance determinant genes	mCIM	Resistance profile	MIC of antimicrobials (μg/ml)
Patients	Isolates	String test	Capsular serotype	Virulence genes	MLST	Resistance determinant genes	mCIM	Resistance profile	MEM	IMI	COL
Patient-1	P-1	Neg	ND	ND	ST16	bla_CTX-M-15, bla_SHV, bla_TEM, bla_NDM-1, bla_OXA-48	Pos	CAZ, CPM, PTZ, ASM, AM, GM, CIP, LEV, NIT	≥32	≥32	12
Patient-2	P-2	Pos	K20	iucA, ybtS	ST16	bla_CTX-M-₁₅, bla_SHV, bla_TEM, bla_NDM-1, bla_OXA-48	Pos	CAZ, CPM, PTZ, ASM, AM, GM, CIP, LEV	≥32	≥32	8
Patient-3	P-3	Neg	ND	ND	ST11	bla_OXA-48	Pos	CAZ, CPM, PTZ, ASM, AM, GM, CIP, LEV, NIT	≥32	16	12
Patient-4	P-4	Neg	ND	ND	ST16	bla_CTX-M-₁₅, bla_SHV, bla_TEM, bla_NDM-1, bla_OXA-48	Pos	CAZ, CPM, PTZ, ASM, AM, GM, CIP, LEV	≥32	≥32	12
Patient-5	P-5	Neg	ND	ND	ST16	bla_CTX-M-15, bla_SHV, bla_TEM, bla_NDM-1, bla_OXA-48	Pos	CAZ, CPM, PTZ, ASM, AM, GM, CIP, LEV	≥32	≥32	16
Patient-6	P-6	Neg	ND	ND	ST16	bla_CTX-M-15, bla_SHV, bla_TEM, bla_NDM-1, bla_OXA-48	Pos	CAZ, CPM, PTZ, ASM, AM, GM, CIP, LEV	≥32	≥32	12
Patient-7	P-7	Neg	ND	ND	ST16	bla_SHV, bla_NDM-1	Pos	CAZ, CPM, PTZ, ASM, AM, GM, CIP, LEV, NIT	≥32	≥32	12
Patient-7	P-8	Neg	ND	ND	ST16	bla_SHV, bla_NDM-1	Pos	CAZ, CPM, PTZ, ASM, AM, GM, CIP, LEV, NIT	≥32	≥32	12

Neg Negative, Pos Positive, ND Not detected, iucA Aerobactin, ybt Yersiniabactin, MLST Multilocus sequence typing, mCIM Modified carbapenem inactivation method, Pos Positive, CAZ Ceftazidime, CPM Cefepime, PTZ Piperacillin/tazobactam, ASM Ampicillin/sulbactam, AM Amikacin, GM Gentamicin, CIP Ciprofloxacin, LEV Levofloxacin, NIT Nitrofurantoin, MEM Meropenem, IMI Imipenem, COL Colistin, MIC Minimal inhibitory concentration

ISSN: 1471-2180