Fig. 6

Identification of microbiota signatures according to NASH status after classification by SIMCAT. The importance of specific microbial taxa for the classification according to NASH status is shown. The weight of individual taxa used for classification is indicated together with individual effect size and robustness of classification. OTUs are named by their lowest taxonomic resolution and are colored according to their classification status (brown: NASH, green: no-NASH). The heatmap indicates taxa as features with sample abundance colored by the corresponding Z-scores. The panel at the bottom of the figures indicates the metadata available to the model (Classification: Result of Enet classification. Gene (cohabitation): Mice raised in the same cage. Genotype: wildtype vs knock-out CH25H^−/−, EBI2^−/−, or CYP7B1.^−/−. Fibrosis: Histology scoring of liver. NASH: Outcome measure of occurrence of NASH. q0: (rarefied) taxa richness).The panel with the title ENET model represents the weight statistic of the model (number of top features and their weight in the complete model)