Table 1 Antimicrobial Resistance (AMR) Genes
Gene | Product | Antibiotic class | Antibiotics | Query coverage | Evalue | Percent identity | Accession |
|---|---|---|---|---|---|---|---|
oxyR | Hydrogen peroxide-inducible genes activator | Isoniazid | Isoniazid | 100% | 0 | 100.00% | WP_119059582.1 |
folP | Dihydropteroate synthase (EC 2.5.1.15) | Sulfonamides | Sulfadiazine,sulfadimidine,sulfadoxine,sulfamethoxazole,sulfisoxazole,sulfacetamide,mafenide,sulfasalazine,sulfamethizole,dapsone | 100% | 0 | 99.30% | WP_119058480.1 |
Rho | Transcription termination factor Rho | Bicyclomycins | Bicyclomycins | 100% | 0 | 98.04% | WP_283670756.1 |
S12p | SSU ribosomal protein S12p (S23e) | Aminoglycosides | Streptomycin | 100% | 5.00E-83 | 100.00% | WP_119057766.1 |
gyrB | DNA gyrase subunit B (EC 5.99.1.3) | Clofazimine,gatifloxacin,ciprofloxacin | Ciprofloxacin | 100% | 0 | 99.54% | WP_119058897.1 |
folA, Dfr | Dihydrofolate reductase (EC 1.5.1.3) | Diaminopyrimidines | Trimethoprim,brodimoprim,tetroxoprim,iclaprim | 100% | 4.00E-114 | 98.77% | WP_119058034.1 |
inhA, fabI | Enoyl-[acyl-carrier-protein] reductase [NADH] | Isoniazid, Ethionamide, Triclosan | Isoniazid,ethionamide,triclosan | 100% | 0 | 99.64% | WP_119057337.1 |
S10p | SSU ribosomal protein S10p (S20e) | Tetracyclines, Glycylcyclines | Tetracycline,tigecycline | 100% | 2.00E-65 | 100.00% | WP_119057769.1 |
Iso-tRNA | Isoleucyl-tRNA synthetase (EC 6.1.1.5) | Mupirocin | Mupirocin (pseudomonic acid) | 99% | 0 | 100.00% | WP_119059585.1 |
gidB | 16S rRNA (guanine(527)-N(7))-methyltransferase (EC 2.1.1.170) | Aminoglycosides | Streptomycin | 100% | 5.00E-142 | 97.57% | WP_119058444.1 |
EF-G | Translation elongation factor G | Fusidic acid | Fusidic acid | 100% | 0 | 99.86% | WP_119057768.1 |
MurA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) | Fosfomycin | Fosfomycin | 100% | 0 | 100.00% | WP_119059381.1 |
rpoC | DNA-directed RNA polymerase beta' subunit (EC 2.7.7.6) | Myxopyronins,Corallopyronins, Peptide | Daptomycin | 100% | 0 | 99.51% | WP_283671279.1 |
Alr | Alanine racemase (EC 5.1.1.1) | Cycloserine | Cycloserine | 100% | 0 | 100.00% | WP_119058724.1 |
kasA | 3-oxoacyl-[acyl-carrier-protein] synthase, KASII (EC 2.3.1.179) | Isoniazid, Triclosan | Isoniazid, Triclosan | 100% | 0 | 99.76% | WP_283671350.1 |
Ddl | D-alanine–D-alanine ligase (EC 6.3.2.4) | Cycloserine | Cycloserine | 100% | 0 | 99.69% | WP_283671268.1 |
EF-Tu | Translation elongation factor Tu | Elfamycins | Kirromycin,enacyloxin IIa,pulvomycin | 100% | 0 | 100.00% | WP_119058163.1 |
rpoB | DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) | Rifamycins, Peptide antibiotics | Rifamycin,daptomycin,rifabutin,rifampin | 100% | 0 | 99.84% | SZD73303.1 |
gyrA | DNA gyrase subunit A (EC 5.99.1.3) | Fluoroquinolones Quinolones Quinolines | Clofazimine,ciprofloxacin,gatifloxacin,levofloxacin,moxifloxacin,nalidixic acid,ofloxacin,sparfloxacin,trovafloxacin | 100% | 0 | 99.64% | WP_283670346.1 |
| Â | Subclass B1 beta-lactamase (EC 3.5.2.6) | Beta-lactam antibiotics | Beta-lactam antibiotics | 100% | 0 | 100% | WP_119059468.1 |