Table 2 Characteristics of the 56 proteins differentially abundant when compared the proteomic profiles from persisters and growing cells (T48hcip vs. Expo)
From: Proteomic characterization of persisters in Enterococcus faecium
Gene | Protein annotation (Uniprot) | Protein description | Log2 FC T48hcip vs. Expoa | Log2 FC T48h vs. Expob |
|---|---|---|---|---|
11,191 | I3U1C7 | M15B subfamily muramoylpentapeptide carboxypeptidase | -8.20 | -5.82 |
10,503 | I3U1A5 | Peptidoglycan-binding protein | -6.80 | -3.53 |
11,429 | Q3XXV0 | Amino acid ABC superfamily ATP binding cassette transporter, binding protein | -5.44 | -4.33 |
mtlD | Q3Y1G8 | Mannitol-1-phosphate 5-dehydrogenase | -4.48 | |
galP | Q3Y292 | MFS transporter, SP family galactose:H + symporter | -4.35 | |
sagA | I3U595 | Secreted antigen A | -4.32 | -2.17 |
11,462 | Q3Y0G5 | Uncharacterized protein | -4.00 | |
12,555 | Q3Y185 | ErfK/YbiS/YcfS/YnhG family protein | -3.66 | -4.78 |
ppiA | Q3XZ44 | Foldase protein PrsA | -3.66 | 1.83 |
rseP | I3U2R6 | Zinc metalloprotease | -3.50 | |
10,635 | Q3Y0A7 | Uncharacterized protein | -3.48 | |
cysK | Q3XX46 | Cysteine synthase | -3.46 | |
10,888 | Q3Y2R0 | Flavodoxin | -3.36 | -1.56 |
10,870 | Q3Y2P3 | Bacteriophage minor structural protein | -3.30 | |
mdoB | Q3XZ26 | Phosphatidylglycerol–membrane-oligosaccharide glycerophosphotransferase | -2.94 | |
murA | Q3XY92 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | -2.84 | -1.72 |
11,465 | Q3Y0G2 | Protein of hypothetical function DUF984 | -2.80 | |
rpmG | I3U4T5 | 50 S ribosomal protein L33 | -2.48 | -2.94 |
rpsN | Q3XYX6 | 30 S ribosomal protein S14 type Z | -2.26 | |
mvk | Q3XZL3 | Mevalonate kinase | -2.24 | |
10,382 | I3TZ18 | NADH:flavin oxidoreductase/NADH oxidase | -2.09 | -2.02 |
10,028 | Q3XYZ5 | Haloacid dehalogenase (HAD) superfamily hydrolase | -1.92 | -2.50 |
pyrD2 | I3U217 | Dihydroorotate oxidase (fumarate) | -1.90 | |
12,850 | Q3Y0Z2 | Uncharacterized protein | -1.82 | |
clpX | Q3XZ71 | ATP-dependent Clp protease ATP-binding subunit ClpX | -1.82 | |
12,761 | I3U5U7 | Uncharacterized protein | -1.78 | |
11,804 | Q3Y303 | MarR family transcriptional regulator | -1.72 | |
pgsA | Q3Y0P3 | CDP-diacylglycerol–glycerol-3-phosphate 3-phosphatidyltransferase | -1.69 | |
murB | Q3Y1W9 | UDP-N-acetylenolpyruvoylglucosamine reductase | -1.67 | |
mobC | I3U5U5 | Mobilization protein C | -1.57 | -3.45 |
12,063 | I3U3U9 | M20/M25/M40 family peptidase | 1.51 | |
polA | I3U2E8 | DNA polymerase I | 1.51 | |
erpQ | Q3XZG3 | ErpQ protein | 1.54 | |
cspA | I3U0N2 | Cold shock protein Csp | 1.57 | -6.12 |
pdp | Q3XXR6 | Pyrimidine-nucleoside phosphorylase | 1.59 | |
accA | Q3Y0R8 | Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha | 1.68 | 2.74 |
glpF | Q3XYL4 | Glycerol MIP family major intrinsic protein channel protein | 1.74 | 2.59 |
10,691 | Q3Y1 × 6 | Flavin reductase | 1.78 | |
papS | I3U153 | Poly A polymerase | 1.96 | |
uxuA | Q3XZP4 | Mannonate dehydratase | 1.97 | |
ahpC | Q3XZP1 | Alkyl hydroperoxide reductase C | 2.02 | |
dacA | I3U3E0 | Serine-type D-Ala-D-Ala carboxypeptidase | 2.05 | 4.42 |
panE | Q3Y316 | 2-dehydropantoate 2-reductase | 2.06 | |
dps | I3U5I6 | DNA-binding protein Dps | 2.10 | |
cad | I3U5L5 | Sex pheromone cAD1 | 2.24 | |
rbsR | I3TZ89 | Ribose transcriptional regulator | 2.33 | |
mdlA | Q3XXU7 | Multidrug ABC superfamily ATP binding cassette transporter, ABC/membrane protein | 2.35 | 1.70 |
12,664 | I3U5K0 | LacI family transcriptional regulator | 2.53 | 2.55 |
pphA | I3U2F5 | Phosphoprotein phosphatase | 2.56 | 2.03 |
12,270 | Q3XWI3 | GNAT family acetyltransferase | 2.78 | |
10,507 | I3TZE3 | GyrI-like domain-containing protein | 2.79 | |
qor | I3TYH2 | NADPH:quinone reductase | 3.03 | |
11,264 | I3U1K0 | Uncharacterized protein | 3.27 | |
msrA4 | Q3XZS1 | Peptide methionine sulfoxide reductase MsrA | 3.65 | 2.17 |
nusB | Q3Y2G2 | Transcription antitermination protein NusB | 3.76 | 2.11 |
tufA;tufA2 | Q3XX23 | Elongation factor Tu | 3.80 | 2.26 |