Table 3 Structural classification of known resistance-associated and novel predictive variants
Variant ID | Gene | Mutation | Uniprot ID | RIN-based simple classification | Observed resistance to | Reported resistance to |
|---|---|---|---|---|---|---|
Known resistance-associated mutations | ||||||
    (7570, ’C,T’, ’snp’) | gyrA | A90V | P9WG47 | Ligand interaction | OFL, ETH | |
    (7362, ’G,C’, ’snp’) | gyrA | E21Q | P9WG47 | Protein interaction | OFL | |
    (781687, ’A,G’, ’snp’) | rpsL | K43R | P9WH63 | RNA interaction | STR | |
    (2154724, ’C,A’, ’snp’) | katG | R463L | P9WIE5 | Surface | STR | |
Previously unreported variants | ||||||
    (781395, ’T,C’, ’snp’) | rpsL | T-164C | P9WH63 | - | STR | - |
    (906857, ’A,G’, ’snp’) | pabC | I145M | Q79FW0 | Protein interaction | ETH | - |
Previously unreported variants with no structural templates (AlphaFold [56] models used) | ||||||
    (1670814, ’C,T’, ’snp’) | DUF58 | G134G | A0A7U4G1E6 | Core | ETH | - |