Fig. 1
From: Reduction of UreB and CagA expression level by siRNA construct in Helicobacter pylori strain SS1
Effect of siRNA on Urease and CagA virulence factors of H. pylori. Urease is a critical factor that facilitates bacterial colonization in the gastric mucosa and hydrolyzes urea to produce ammonia and CO2. Proteins such as blood group antigen binding adhesin A (BabA), sialic acid–binding adhesin (SabA), and outer inflammatory protein A (OipA) produced by this pathogen contribute to colonization and persistence of infection. CagA protein directly targets gastric epithelium and CagA-mediated carcinogenesis occurs. In the siRNA pathway, full complementary binding between the siRNA guide strand and the target mRNA leads to mRNA cleavage. In other words, siRNA reduces or inhibits the expression level of ureB and cagA genes, which results in the reduction of colonization and inflammation. The figure is created using BioRender.com