Fecal microbiota transplantation as a therapy for treating ulcerative colitis: an overview of systematic reviews

BMC Microbiology

Table 7 Evidence quality of re-analysis on FMT for UC with data from primary trials

Outcomes	№ of trials	Certainty assessment					№ of patients		OR (95% CI)	Quality
Outcomes	№ of trials	Limitations	Inconsistency	Indirectness	Imprecision	Publication bias	Experimental	Control	OR (95% CI)	Quality
CER	8	No	No	No	No	No	190	194	3.83 [2.31, 6.34]	⨁⨁⨁⨁⨁ High
Clinical remission	8	No	No	No	No	No	214	214	3.31 [2.09, 5.25]	⨁⨁⨁⨁⨁ High
Endoscopic remission	7	No	No	No	No	No	193	195	3.75 [2.20, 6.39]	⨁⨁⨁⨁⨁ High
Clinical response	7	No	No	No	No	No	173	175	2.56 [1.64, 4.00]	⨁⨁⨁⨁⨁ High
Endoscopic response	4	No	No	No	Serious^c	No	86	93	2.18 [1.12, 4.26]	⨁⨁⨁⨁◯ Moderate
ADs	9	No	No	No	No	No	226	226	1.53 [0.74, 3.19]	⨁⨁⨁⨁⨁ High

CER Combined clinical and endoscopic remission, Ads Severe adverse events
^aThe experimental design had a large bias in random, distributive findings or was blind
^bThe confidence interval overlaps less, the heterogeneity test P was very small, and the I² was larger
^cThe Confidence interval was not narrow enough, or the simple size is too small
^dFunnel graph asymmetry, or fewer studies were included and there may have been greater publication bias

ISSN: 1471-2180