Table 6 Evidence quality of the included reviews
Review | Outcomes | № of trials | Design | Certainty assessment | № of patients | Relative effect (95% CI) | Quality | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Limitations | Inconsistency | Indirectness | Imprecision | Publication bias | Experimental | Control | ||||||
Narula, 2017 [26] | CER | 4 | Rct | No | No | No | Seriousc | No | 140 | 137 | RR 2.97 [1.66, 5.33] | ⨁⨁⨁⨁◯ Moderate |
Clinical remission | 4 | Rct | No | No | No | Seriousc | No | 140 | 137 | RR 1.87 [1.29, 2.70] | ⨁⨁⨁⨁◯ Moderate | |
Endoscopic remission | 4 | Rct | No | Seriousb | No | Seriousc | No | 140 | 137 | RR 3.26 [1.90, 5.59] | ⨁⨁⨁◯◯ Low | |
ADs | 4 | Rct | No | No | No | Seriousc | No | 140 | 137 | RR 1.40 [0.55, 3.58] | ⨁⨁⨁⨁◯ Moderate | |
Dang, 2020 [27] | Clinical remission | 4 | Rct | No | No | No | Seriousc | No | 140 | 137 | OR 3.47 [1.93, 6.25] | ⨁⨁⨁⨁◯ Moderate |
Clinical response | 4 | Rct | No | Seriousb | No | Seriousc | No | 140 | 137 | OR 2.48 [1.18, 5.21] | ⨁⨁⨁◯◯ Low | |
ADs | 4 | Rct | No | No | No | Seriousc | No | 140 | 137 | OR 1.29 [0.46, 3.57] | ⨁⨁⨁⨁◯ Moderate | |
Tang, 2020 [28] | Clinical remission | 7 | Rct | No | No | No | No | No | 217 | 214 | OR 2.29 [1.48, 3.53] | ⨁⨁⨁⨁⨁ High |
ADs | 6 | Rct | No | No | No | No | No | 210 | 206 | RR 1.37 [0.63, 2.96] | ⨁⨁⨁⨁⨁ High | |
Liu, 2021 [29] | CER | 5 | Rct | No | No | No | Seriousc | No | 147 | 145 | RR 3.14 [1.78, 5.55] | ⨁⨁⨁⨁◯ Moderate |
Clinical remission | 5 | Rct | No | No | No | Seriousc | No | 147 | 145 | RR 1.85 [1.28, 2.67] | ⨁⨁⨁⨁◯ Moderate | |
Endoscopic remission | 5 | Rct | No | No | No | Seriousc | No | 147 | 145 | RR 2.26 [1.28, 5.53] | ⨁⨁⨁⨁◯ Moderate | |
ADs | 5 | Rct | No | No | No | Seriousc | No | 147 | 145 | RR 0.98 [0.93, 1.03] | ⨁⨁⨁⨁◯ Moderate | |
El, 2022 [30] | CER | 6 | Rct | No | No | No | No | No | 161 | 163 | OR 4.11 [2.19,7.72] | ⨁⨁⨁⨁⨁ High |
Clinical remission | 4 | Rct | No | No | No | Seriousc | No | 117 | 120 | OR 3.06 [1.35, 6.89] | ⨁⨁⨁⨁◯ Moderate | |
Clinical response | 6 | Rct | No | No | No | No | No | 161 | 163 | OR 2.60 [1.54, 4.40] | ⨁⨁⨁⨁⨁ High | |
Endoscopic remission | 4 | Rct | No | No | No | Seriousc | No | 132 | 132 | OR 3.78 [1.59, 8.97] | ⨁⨁⨁⨁◯ Moderate | |
Endoscopic response | 3 | Rct | No | No | No | Seriousc | No | 79 | 95 | OR 2.17 [1.05, 4.50] | ⨁⨁⨁⨁◯ Moderate | |
ADs | 6 | Rct | No | No | No | No | No | 161 | 163 | OR 1.38 [0.58, 3.30] | ⨁⨁⨁⨁⨁ High | |
Wei, 2022 [31] | Clinical remission | 9 | Rct | No | No | No | No | No | 213 | 212 | RR 1.84 [1.37, 2.47] | ⨁⨁⨁⨁⨁ High |
Endoscopic remission | 7 | Rct | No | No | No | No | No | 195 | 194 | RR 1.94 [1.14, 3.31] | ⨁⨁⨁⨁⨁ High | |
ADs | 9 | Rct | No | No | No | No | No | 213 | 212 | RR 2.05 [1.03, 4.09] | ⨁⨁⨁⨁⨁ High | |