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Table 1 Demographic characteristics and clinical data for the participants

From: Multi-omics analyses of gut microbiota via 16S rRNA gene sequencing, LC-MS/MS and diffusion tension imaging reveal aberrant microbiota-gut-brain axis in very low or extremely low birth weight infants with white matter injury

Character

WMI (n = 23)

nWMI (n = 48)

P

Gestational age (\(\overline{x}\) ± s, week)

30.0 ± 1.8

29.9 ± 1.7

0.607

Birth weight (\(\overline{x}\) ± s, kg)

1.32 ± 0.21

1.30 ± 0.22

0.663

Male (n, %)

12(52.2%)

29(60.4%)

0.511

Caesarean section (n, %)

14(60.8%)

21(43.7%)

0.177

IVF-ET (n, %)

3(13%)

10(20.8%)

0.427

Asphyxia (n, %)

9(39.1%)

19(39.5%)

0.971

Hypothermia at birth (n, %)

13(56.5%)

25(52%)

0.726

SGA (n, %)

1(4.3%)

3(6.2%)

0.745

Hypoglycemia (n, %)

5(21.7%)

13(27%)

0.628

Positive pressure ventilation time (IQR, day)

10(7, 13)

6(6.3, 10.5)

0.281

Duration of antibiotic use (IQR, day)

6(5, 9.1)

5.5(4.6, 6.9)

0.188

Sepsis (n, %)

10(43.4%)

20(41.6%)

0.885

Digestive complications (n, %)

13(56.5%)

31(66.6%)

0.406

Total intestinal feeding time (IQR, day)

18.5(15, 23)

15.5(15, 19)

0.317

EUGR (n, %)

15(65.2%)

27(56.2%)

0.472

BPD (n, %)

4(17.3%)

9(18.7%)

0.89

Length of stay (\(\overline{x}\) ± s,day)

50.13 ± 17.4

50.88 ± 13.3

0.391

Premature rupture of fetal membranes (n, %)

7(30.4%)

8(16.6%)

0.184

Prenatal hormones (n, %)

10(43.4%)

23(47.9%)

0.726

Prenatal antibiotic use (n, %)

12(52.1%)

18(37.5%)

0.241

GDM (n, %)

2(8.6%)

12(25%)

0.106

Preeclampsia (n, %)

2(8.6%)

10(20.8%)

0.202

  1. IVF-ET In vitro fertilization-embryo transfer; IQR Interquartile range; SGA Small for gestational age; BPD bronchopulmonary dysplasia; GDM Gestational diabetes mellitus; EUGR Extrauterine growth retardation