Table 9 Effect of purified EPSs produced by F. nygamai strain AJTYC1 on normal THLE2, MCF7, HCT116 and HepG2 cells
Cell line | Conc. of EPS µg/ml | Viability % | Toxicity % | IC50 µg/ml |
|---|---|---|---|---|
THLE2 | 1000 | 9.25 | 90.75 | 476.8 |
500 | 40.9 | 59.10 | ||
250 | 78.5 | 21.50 | ||
125 | 99.0 | 1.00 | ||
62.5 | 99.2 | 0.80 | ||
31.25 | 99.7 | 0.30 | ||
MCF7 | Control | 100 | 0 | 417.6 |
1000 | 7.25 | 92.75 | ||
500 | 35.6 | 64.36 | ||
250 | 76.5 | 23.45 | ||
125 | 99.8 | 0.185 | ||
62.5 | 99.9 | 0.139 | ||
31.25 | 99.9 | 0.046 | ||
HCT116 | Control | 100 | 0 | 334.6 |
1000 | 5.10 | 94.90 | ||
500 | 16.57 | 83.43 | ||
250 | 67.21 | 32.79 | ||
125 | 98.53 | 1.471 | ||
62.5 | 99.85 | 0.147 | ||
31.25 | 100 | 0 | ||
HepG2 | Control | 100 | 0 | 448.3 |
1000 | 2.72 | 97.28 | ||
500 | 36.49 | 63.51 | ||
250 | 89.382 | 10.62 | ||
125 | 98.222 | 1.78 | ||
62.5 | 99.26 | 0.74 | ||
31.25 | 99.36 | 0.64 |