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Fig. 4 | BMC Microbiology

Fig. 4

From: Increased bacterial taxonomic and functional diversity is associated with impaired rotavirus vaccine immunogenicity in infants from India and Malawi

Fig. 4

Volcano plots of feature enrichment by oral rotavirus vaccine seroconversion. Italicised numbers display the number of features with a prevalence difference of < 0 (left of vertical dotted line) or ≥ 0 (right of vertical dotted line), highlighting features enriched in non-seroconverters and seroconverters, respectively. The horizontal dotted line indicates an FDR p value of 0.2. The significance tests below the italicised numbers indicate the results of a Wilcoxon rank-sum test assessing skew in the distribution of associations (with a null hypothesis that negative and positive associations occur with equal frequency). Analyses for Indian infants are reported for the overall cohort and stratified by neonatal wild-type rotavirus exposure. EC, enzyme commission; FDR, false discovery rate; IND, India; MLW, Malawi; neo + , infected with rotavirus neonatally (defined by detection of rotavirus shedding in week of life 1 or baseline seropositivity); neo-, uninfected with rotavirus neonatally; sero + , seroconverters; sero-, non-seroconverters; ** p < 0.005; *** p < 0.0005

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BMC Microbiology

ISSN: 1471-2180

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