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Fig. 3 | BMC Microbiology

Fig. 3

From: Increased bacterial taxonomic and functional diversity is associated with impaired rotavirus vaccine immunogenicity in infants from India and Malawi

Fig. 3

Association between microbiome composition and oral rotavirus vaccine seroconversion. Data are shown for (A) genus, (B), species, (C) pathway, and (D) enzyme commission data. The left panels display comparisons of feature richness by seroconversion. Groups were compared by Wilcoxon rank-sum test. The middle panels display the cross-validation accuracy of Random Forests for prediction of seroconversion. Median out-of-bag accuracy (proportion correctly assigned) and interquartile range across 20 iterations of fivefold cross-validation are displayed. Each iteration included an equal number of responders and non-responders (50 per group where possible, or else the number in the minority group if this was < 50). The right panels display the number of enriched features based on prevalence (Fisher’s exact test) and abundance (MaAsLin2). Analyses for Indian infants are reported for the overall cohort and stratified by neonatal wild-type rotavirus exposure. CV, cross-validation; EC, enzyme commission; FDR, false discovery rate; IND, India; MLW, Malawi; n.s., not significant; neo + , infected with rotavirus neonatally (defined by detection of rotavirus shedding in week of life 1 or baseline seropositivity); neo-, uninfected with rotavirus neonatally; * p < 0.05; ** p < 0.005; *** p < 0.0005

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BMC Microbiology

ISSN: 1471-2180

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