Investigating the antimicrobial activity, cytotoxicity, and action mechanism of acylated and amidated derivatives of AurH1 antifungal peptide

Table 1 MICs and MBCs (MFCs) in µg/mL against selected bacteria and fungi

Microorganism	Means of MIC/MBC (MFC) for 3 independent tests
Microorganism	AurH1^*	Ac-AurH1	AurH1-NH₂	Pen	Strep	Nys	Flu
*S. aureus*	> 1000	> 1000	> 1000	0.45/NA	62.50/NA
*E. coli*	> 1000	> 1000	> 1000	31.25/NA	3.9/ NA
*C. abicans*	15.625/125	250/>1000	7.81/62.50			1.95/3.90	62.50/500
*C. glabrata*	125/500	> 1000	62.50/62.50			3.90/3.90	125/500
*C. krusei*	31.25/250	500/>1000	7.81/31.25			1.95/3.90	62.50/250
*A. niger*	125/500	> 1000	125/500			31.25/125	500/>1000
*A. flavus*	> 1000	> 1000	250/1000			7.81/62.50	> 1000

Pen: Penicillin, Strp: Streptomycin, Nys: Nystatin, Flu: Fluconazole
* The results related to AurH1 are included based on the results of our previous study

ISSN: 1471-2180