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Table 1 Baseline characteristics and outcome

From: The gut-lung axis in critical illness: microbiome composition as a predictor of mortality at day 28 in mechanically ventilated patients

 

Deceased(27)

Survival(35)

P

Age

63(53, 69)

58(45, 75)

0.121

length of ICU stay(d)

17(11, 23)

13(8, 23)

0.286

level of PEEP

8.78 ± 3.85

6.54 ± 2.09

0.005

Days of mechanical ventilation

16.54 ± 8.75

13.93 ± 7.08

0.210

Enteral nutrition time(d)

2(1, 4)

2(1, 4)

0.896

SOFA

14(12, 16)

13(8, 14)

0.098

Antifungal

11

11

0.447

Sex(Male)

15

17

0.585

Emergency Surgery

11

12

0.602

Smoking history

7

6

0.400

Alcohol history

7

7

0.580

VAP

17

19

0.492

ARDS

21

22

0.206

Early enteral nutrition (72 h)

20

26

0.985

Diagnosis-abdominal surgery

3

8

0.321

Diagnosis-hematopathy

3

4

1.000

Diagnosis-Rheumatic immune disease

2

3

1.000

Diagnosis-respiratory disease

9

5

0.124

Diagnosis-neurosurgery

10

10

0.480

Diagnosis-respiratory disease

0

5

0.063

complication-hypertension

4

5

1.000

complication-diabetes

4

3

0.698

complication-cardiovascular disease

5

4

0.485

complication-tumour

4

5

1.000

complication-Neuropathy

4

6

1.000

Catecholamine

  

0.371

Not in Use

4(38.5%)

9(69.2%)

 

Dopamine ≤ 5ug/kg/mim

8(61.5%)

5(38.5%)

 

Dopamine > 5ug/kg/mim

or adrenal dose ≤ 0.1ug/kg/min

or norepinephrine dose ≤ 0.1ug/kg/min

4(33.3%)

8(66.7%)

 

Dopamine > 15ug/kg/mim

or adrenal dose > 0.1ug/kg/min

or norepinephrine dose > 0.1ug/kg/min

11(45.8%)

13(54.2%)

 

Antibiotics

 Carbapenems

16

16

0.290

 Cephalosporins

9

13

0.756

 β- Lactam antibiotics

12

14

0.725

 Tegacyclin

9

6

0.140

 Aminoglycoside

0

2

0.500

 Anti positive bacteria

16

16

0.290

 Quinolone

3

3

1.000

 Polymyxin

2

3

1.000

 Anti anaerobic bacteria

1

0

0.436

BALF traditional culture

 Enterobacter aerogenes

6

6

0.616

 CRAB

3

7

0.491

 CRKP

14

18

0.974

 CRPA

6

7

0.831

 MRSA

4

10

0.199

 Neisseria

5

5

0.735

 Stenotrophomonas maltophilia

4

4

0.719

 Burkholderia cepacia

2

3

1.000

 Chryseobacterium indologenes

3

3

1.000

  1. Data presented as median with [IQR]
  2. PEEP positive end-expiratory pressure, SOFA Sequential Organ Failure Assessment. Anti-positive bacteria: vancomycin or linezolid. Anti anaerobic bacteria: ornidazole. VAP Ventilator associated pneumonia, ARDS acute respiratory distress syndrome, CRAB Cabapemne Resistant Acinetobacter Baumannii, CRKP carbapenem-resistant Klebsiella pneumoniae, CRPA Carbapenem-resistant Pseudomonas aeruginosa, MASA methicillin-susceptible Staphylococcus aureus