Fig. 6

Difference analysis between hypoleukocytes and normal leukocytes group after CRC chemotherapy. A The t-test method was used to test the hypothesis of the gut microbiota of the two groups and evaluate the significance level of the difference in the abundance of the bacteria. P<0.05 was considered statistically significant. B LDA was used to draw histograms and count the gut microbiota with significant differences between the two groups. LDA scores were obtained using linear regression analysis. The greater the score, the greater the influence of gut microbiota abundance on differential effects. C From inner circle to outer circle, the bacteria at different levels of phylum, class, order, family, genus, and species are represented in turn. Different colored nodes indicate the degree of enrichment of bacteria in the corresponding group and whether they have a significant effect on the difference between groups. Species with no significant differences are uniformly colored yellow, and red nodes indicate gut microbiota with significant differences