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Fig. 5 | BMC Microbiology

Fig. 5

From: Angelica polysaccharides relieve blood glucose levels in diabetic KKAy mice possibly by modulating gut microbiota: an integrated gut microbiota and metabolism analysis

Fig. 5

LC–MS/MS-based untargeted metabolic profiling in positive and negative modes discovered that AP changes gut metabolome in HFD KKAy mice (n = 5). A, B The PLS-DA analysis showed clear separation among three groups in the positive model (R2X = 0.555, R2Y = 0.99, Q2Y = 0.798) and in the negative model (R2X = 0.582, R2Y = 0.993, Q2Y = 0.781). C, D With the criteria of either VIP > 1 and p < 0.05, the Venn diagram showed the number of differential metabolites between groups. 42 metabolites were up-regulated by HFD and reversed by AP, 29 metabolites were down-regulated by HFD and reversed by AP. E The differential metabolites class categories between HFD and AP groups. F The top 20 of KEGG enrichment analysis based on the differential metabolites between HFD and AP groups

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BMC Microbiology

ISSN: 1471-2180

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