Fig. 1
From: LYZ2-SH3b as a novel and efficient enzybiotic against methicillin-resistant Staphylococcus aureus
Schematic representation of gp61, Lysostaphin, and LYZ2-SH3b domains. The enzyme gp61, as a type of exolysin, is synthesized by the phage ΦMR11. Gp61 has two different catalytic domains CHAP (Cysteine, histidine-dependent amidohydrolases/peptidases) and an LYZ2 domain. The bacteriocin lysostaphin is an enzyme produced by Staphylococcus simulans. This enzyme has a C-terminal cell-binding domain (SH3b) and a catalytic domain (Prepropeptidase). LYZ2-SH3b is the chimeric protein generated for this study, and it is composed of the LYZ2 domain from gp61 and the SH3b cell-binding domain from Lysostaphin