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Table 1 Demographic and clinical characteristics of pregnant women enrolled

From: Profiles and integration of the gut microbiome and fecal metabolites in severe intrahepatic cholestasis of pregnancy

Variables

Control (n = 20)

ICP(Mild, n = 20)

ICP(Severe, n = 20)

p

Age (year-old)

29.55 ± 3.24

31.10 ± 4.17

32.00 ± 4.05†

0.134

BMI before pregnancy (kg•m−2)

20.97 ± 2.84

21.16 ± 2.44

21.35 ± 2.44

0.895

Parity

   

0.551

 Primiparous

15(75%)

13(65%)

16(80%)

 

 Multiparous

5(25%)

7(35%)

4(20%)

 

Education Background

   

0.192

 Junior College

1(5%)

1(5%)

2(10%)

 

 Undergraduate

15(75%)

17(85%)

14(70%)

 

 Postgraduate

4(20%)

2(10%)

4(20%)

 

Gestational Weeks at sampling

36.61 ± 1.50

35.99 ± 2.16

34.44 ± 5.74

0.162

Gestational Weeks at delivery

39.02 ± 1.25

37.49 ± 1.33#

36.78 ± 1.55†

 < 0.001

Newborn Weight (g)

3230.50 ± 474.71

2948.25 ± 509.36

2831.75 ± 370.43†

0.023

TBA(μmol•L−1)

3.75 ± 2.40

19.80 ± 8.89#

49.35 ± 16.56†‡

 < 0.001

TBIL(μmol•L−1)

7.64 ± 2.26

8.12 ± 3.05

9.23 ± 4.33

0.308

DBIL(μmol•L−1)

2.05 ± 0.50

2.40 ± 0.84

2.15 ± 2.25

0.462

ALT (U•L−1)

10.00

(7.00–14.75)

19.00

(10.00–102.25)#

10.00

(7.00–173.25)

0.042

AST (U•L−1)

15.00

(12.25–18.00)

22.00

(13.25–47.50)

16.50

(12.00–96.50)

0.130

ALP (U•L−1)

135.00

(105.50–164.00)

159.00

(121.50–228.00)

122.00

(86.50–149.00)‡

0.036

γ-GT (U•L−1)

8.00

(5.25–23.25)

23.00

(8.00–54.25)

10.50

(9.00–14.75)

0.122

LDH (U•L−1)

178.25 ± 41.81

185.30 ± 33.29

194.50 ± 46.22

0.455

Albumin (g•L−1)

38.95 ± 3.55

34.02 ± 2.97

34.47 ± 2.97†

 < 0.001

Albumin/Globulin

1.43 ± 0.18

1.29 ± 0.18#

1.37 ± 0.19

0.051

  1. Normally distributed continuous variables are shown as means with standard deviations. Variables with significant deviation from normal distribution are shown as median and quartiles. Frequencies with percentages are used to present categorical variables
  2. #means significant difference between Control group and Mild ICP group (p < 0.05)
  3. †means significant difference between Control group and Severe ICP group (p < 0.05)
  4. ‡means significant difference between Mild ICP group and Severe ICP group (p < 0.05); Placenta Ratio refers to ratio of Placenta Weight over Newborn Weight