Characterization of novel bacteriophage PSKP16 and its therapeutic potential against β-lactamase and biofilm producer strain of K2-Hypervirulent Klebsiella pneumoniae pneumonia infection in mice model

Table 3 Comparing of grading of histopathological lesions in lungs and comparing therapeutic potential of phage with antibiotic-phage treatment. mild ( +), moderate (+ +), severe (+ + +) and widespread (+ + + +)

	Time post infection	Group	Groups		Groups
	Time post infection	A	B1	B2	C1	C2
Necrosis of alveolar	48hpi	+ + + +	+	+ + +	+ +	+ + +
Necrosis of alveolar	7^th dpi	+ + + +	-	+ +	+	+ +
Bronchiolitis with inflammatory exudate in lumen	48hpi	+ + +	-	+ +	+	+ +
Bronchiolitis with inflammatory exudate in lumen	7^th dpi	+ +	-	+	-	+
Infiltration of inflammatory cells	48hpi	+ + + +	+ +	+ + +	+ +	+ + +
Infiltration of inflammatory cells	7^th dpi	+ + +	+	+ +	+	+ +
Peribranchial and perivascular infiltration	48hpi	+ + +	+	+ + +	+ +	+ + +
Peribranchial and perivascular infiltration	7^th dpi	+ + +	-	+ +	+	+ +

ISSN: 1471-2180