Table 4 WGS performance in identifying drug-resistance mechanisms of MDR-Kp strains
Type of antibiotics | Antibiotics | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Accuracy (%) | |
|---|---|---|---|---|---|---|---|
β-lactams | Penicillins | Ticarcillin | 100 | / | 100 | / | 100 |
Piperacillin | 100 | / | 100 | / | 100 | ||
Amoxicillin/ Clavulanic acid | 100 | / | 100 | / | 100 | ||
Cephalosporins | Cephalothin | 60 | / | 100 | 0 | 60 | |
Cefuroxime | 60 | / | 100 | 0 | 60 | ||
Cefotaxime | 100 | / | 100 | / | 100 | ||
Ceftazidime | 100 | / | 100 | / | 100 | ||
Cefepime | 100 | 50 | 94.1 | / | 94.4 | ||
Cefazolin | 87.5 | / | 100 | 0 | 87.5 | ||
Cefoxitin | 57.1 | 100 | 100 | 25 | 62.5 | ||
Ceftriaxone | 100 | / | 100 | / | 100 | ||
Carbapenems | Imipenem | 87.5 | 100 | 100 | 50 | 88.9 | |
Meropenem | 100 | / | 100 | / | 100 | ||
Ertapenem | \ | 100 | \ | 100 | 100 | ||
Penicillin/β-lactamase inhibitor | Piperacillin/ Tazobactam | 93.3 | 100 | 100 | 75 | 94.4 | |
Monobactams | Aztreonam | 100 | 0 | 77.8 | 0 | 77.8 | |
Quinolones | Moxifloxacin | 90 | / | 100 | / | 90 | |
Norfloxacin | 90 | / | 100 | / | 90 | ||
Ciprofloxacin | 83.3 | / | 100 | 0 | 83.3 | ||
Levofloxacin | 77.8 | / | 100 | 0 | 77.8 | ||
Aminoglycosides | Tobramycin | 100 | 66.7 | 93.8 | 100 | 94.4 | |
Amikacin | 100 | 100 | 100 | 100 | 100 | ||
Tetracyclines | Tetracycline | 71.4 | / | 100 | 60 | 80 | |
Doxycycline | 71.4 | 100 | 100 | 60 | 80 | ||