Lyme borreliosis diagnosis: state of the art of improvements and innovations

BMC Microbiology

Table 4 Sensitivity of culture detection and PCR assays depending of the origin of clinical sample

Methods	Origin of clinical sample	Sensitivity range	References
Culture of *B. burgdorferi*	Skin biopsies from EM	40 – 90%	[36, 149, 151]
	Skin biopsies from ACA	20 – 60%	[36]
	Skin biopsies from Borrelial lymphocytoma	24 – 32%	[147]
	Synovial fluid/biopsy	< 1%	[36]
	Cerebrospinal fluid	10 – 26%	[29, 36]
	Blood	5 – 40%	[29, 36, 149]
	Urine	nd	[152]
Traditional PCR assays	Skin biopsies from EM	30 – 89%	[29, 153]
	Skin biopsies from ACA	20 – 100%	[29, 153]
	Skin biopsies from Borrelial lymphocytoma	67.5%	[154]
	Synovial fluid/biopsy	40 – 96%	[36, 155, 156]
	Cerebrospinal fluid	5 – 30%	[36, 147, 155]
	Blood	10 – 20%	[36, 147, 155]
	Urine	nd	[152]

ISSN: 1471-2180