Lyme borreliosis diagnosis: state of the art of improvements and innovations

BMC Microbiology

Table 1 Sensitivity and specificity for STTT in America and in Europe

Symptoms / Stage of the disease	Patient's localization
	America			Europe
	Sensitivity^a	Specificity^b	References	Sensitivity	Specificity	References
Erythema migrans or early Lyme borreliosis Acute phase^c (AP)	11–50%	99%	[29, 34, 54,55,56,57]	23–55%	75–99%	[34, 58,59,60,61]
Erythema migrans or early Lyme borreliosis Convalescent phase^d (CP)	18–78%	99%		30–67%	95%	[61]
Acute-phase neurologic or cardiac involvement	60–100%	99%		69–97%	98–99%	[58, 61]
Arthritis or late neurologic involvement	97–100%	99%		78–100%	98–99%	[58, 61]

^aAbility of the test to identify the presence of a disease correctly (CDC)
^bAbility of the test to identify the absence of a disease correctly (CDC)
^cPhase during an active infection, characterized by active multiplication of the pathogens and pronounced symptoms
^dPhase after the antibiotic treatment

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