Propranolol restores susceptibility of XDR Gram-negative pathogens to meropenem and Meropenem combination has been evaluated with either tigecycline or amikacin

Table 3 Effects of PR on the MIC of Meropenem

Isolate code	MICs (μg/ml) MEM alone	PR 0.5 mg /ml		PR 1 mg /ml
Isolate code	MICs (μg/ml) MEM alone	MICs (μg/ml) MEM + PR 0.5 mg /ml	MDF	MICs (μg/ml) MEM + PR 1 mg /ml	MDF
AB-9G	256	32	8	2	128
AB-109A	256	16	16	1	256
AB-63 M	1024	32	32	2	512
AB-30G	512	256	2	1	512
AB-100 M	1024	32	32	2	512
AB-55 M	1024	512	2	1	1024
AB-20G	256	8	32	2	128
AB-3 M	512	8	64	1	512
AB-37 M	1024	32	32	2	512
AB-34 M	128	64	2	0.5	256
AB-14 M	128	8	16	2	64
AB-13 M	512	256	2	2	256
AB-7G	512	8	64	0.5	1024
KP-84S	64	2	8	2	128
KP-89S	128	2	64	0.5	256
KP-114S	1024	64	16	1	1024
KP-25S	1024	128	8	4	256
KP-92A	1024	32	32	4	256
KP-106S	512	32	16	1	512
KP-79A	512	32	16	1	512
KP-113S	512	64	8	2	256
PA-50S	256	4	64	1	256
PA-99S	1024	64	16	4	256
PA-54S	1024	32	32	2	512
PA-78S	128	4	32	0.5	256
EC-55A	512	64	8	4	128
EC-34R	64	8	8	0.5	128
EC-99A	256	16	16	1	256

Abbreviations: MICs minimum inhibitory concentrations, MDF MIC decrease factor, MEM Meropenem, PR Propranolol, AB A. baumannii, KP K. pneumoniae, PA P. aeruginosa, EC E. coli

ISSN: 1471-2180