Fig. 8
From: Antibiotic-induced gut microbiota dysbiosis has a functional impact on purine metabolism
The antimicrobial spectrum was connected to the purine salvage pathway. (a) The taxonomic tree in NC and NC-Ab groups. (b) The taxonomic tree in M and M-Ab groups. The proteins involved in the salvage pathway from (c) Shigella flexneri, (d) Sutterella, (e) Xenorhabdus were absent. (f) Enterococcus casseliflavus enriched three of the proteins of the salvage pathway. (g) Desulfovibrio aespoeensis enriched four of the proteins of the salvage pathway. Nodes were colored with specific role: Purine nucleotide salvage (red), purine ribonucleoside salvage (blue), IMP salvage (green), GMP salvage (yellow) and not purine salvage pathway (all colors). HUA, hyperuricemia; M, hyperuricemia model mouse; M-Ab, antibiotic-fed hyperuricemia model mouse; UA, uric acid; NC, control; NC-Ab, control-antibiotic-fed