Table 3 Important features identified by volcano plot in N & OST

1

Phosphoarginine

12.551

3.6498

8.7424e-06

up

2

Xanthine

8.5894

3.1026

0.00010962

up

3

Aminolevulinic acid

12.474

3.6409

0.001194

up

4

o-Succinylbenzoate

0.30746

-1.7015

0.0019324

down

5

4-Nitrophenol

7.6822

2.9415

0.0025816

up

6

Dihydropteroic acid

4.4263

2.1461

0.0051274

up

7

2-Methoxyestrone 3-sulfate

3.2382

1.6952

0.0093508

up

8

2-(6’-methylthio)hexylmalic acid

0.46843

-1.0941

0.011958

down

9

Zalcitabine

0.41295

-1.276

0.013035

down

10

3,4-Dihydroxyphenylglycol O-sulfate

9.3213

3.2205

0.013586

up

11

Norepinephrine sulfate

0.22231

-2.1693

0.029922

down

12

fructosylglycine

2.7231

1.4453

0.031641

up

13

tetrathionic acid

2.1023

1.0719

0.033801

up

14

(E)-Ferulic acid

2.0952

1.0671

0.048625

up

15

L-Proline

0.001889

-9.0482

7.2329e-12

down

16

Irbesartan

0.00075929

-10.363

3.7902e-11

down

17

Phloionolic acid

0.0028703

-8.4446

1.3835e-10

down

18

Enalapril

0.0081559

-6.9379

8.6221e-10

down

19

L-Threonine

0.0060897

-7.3594

2.771e-09

down

20

DL-Serine

0.0042373

-7.8826

5.8641e-09

down

21

Amoxicillin

0.011054

-6.4993

4.104e-08

down

22

urobilinogen

19.09

4.2548

9.771e-08

up

23

Pipecolic acid

0.012253

-6.3508

2.6359e-07

down

24

N-Acetylhistamine

0.020567

-5.6035

8.5136e-07

down

25

Crotonic acid

0.030598

-5.0304

5.1701e-06

down

26

Aminolevulinic acid

7.5296

2.9126

8.6311e-06

up

27

Isoliquiritigenin

0.072636

-3.7832

9.9385e-06

down

28

Cinnamic acid

14.089

3.8165

1.3218e-05

up

29

DL-Tryptophan

16.092

4.0082

1.734e-05

up

30

(-)-codeine

7.5433

2.9152

1.7647e-05

up

31

Ofoxacin

17.909

4.1626

3.4116e-05

up

32

2,3,4,5-tetrahydrodipicolinic acid

39.965

5.3207

4.278e-05

up

33

D-Alanyl-D-alanine

4.6462

2.2161

6.0808e-05

up

34

Thymine

14.686

3.8764

6.0812e-05

up

35

g-Butyrobetaine

5.2098

2.3812

6.7153e-05

up

36

Daidzein

12.957

3.6957

6.8347e-05

up

37

Stearic acid

0.1786

-2.4852

7.4136e-05

down

38

L-Phenylalanine

0.1954

-2.3555

9.463e-05

down

39

Cholest-4-en-3-one

15.548

3.9586

0.00023261

up

40

L-( +)-Leucine

38.539

5.2683

0.00023661

up

41

L-Tyrosine

2.9931

1.5817

0.00023666

up

42

Styrene

0.047016

-4.4107

0.00030534

down

43

L-Theanine

56.025

5.808

0.00053619

up

44

Acetylcholine

2.6748

1.4194

0.00054292

up

45

cholic acid

5.7303

2.5186

0.00061697

up

46

glutaral

0.11453

-3.1262

0.0007078

down

47

Indole-3-acetic acid

2.6714

1.4176

0.00097212

up

48

3-(3,4-dihydroxypheny]) propanoic acid

2.6031

1.3803

0.0013811

up

49

Chrysin

161.83

7.3383

0.001399

up

50

Tiglic acid

2.6267

1.3932

0.0014194

up

51

Creatine

144.07

7.1706

0.0015611

up

52

L-Isoleucine

2.9603

1.5657

0.0016086

up

53

Deanol

0.30279

-1.7236

0.0016419

down

54

7-ketodeoxycholic acid

0.30624

-1.7073

0.0017631

down

55

Proline

0.028507

-5.1325

0.0018182

down

56

Amide C18

0.32731

-1.6113

0.0026659

down

57

Hypoxanthine

0.34182

-1.5487

0.0028131

down

58

Isoleucine

4.2212

2.0777

0.0028639

down

59

Ursolic acid

0.35954

-1.4758

0.0031063

down

60

Berberine

101.27

6.662

0.0034375

up

61

Diethyl phosphate

0.22342

-2.1622

0.0036987

down

62

Glycochenodeoxycholic acid

2.5592

1.3557

0.0039483

up

63

N(1)-acetylspermidine

0.087937

-3.5074

0.0041961

down