Table 2 Comparison of LD50 values obtained by regular and persister (after meropenem exposure) Acinetobacter baumannii Acb-1 in Galleria mellonella larvae at different times of infection
From: Increased ompW and ompA expression and higher virulence of Acinetobacter baumannii persister cells
Time of infection | Acinetobacter baumannii Acb-1 | LD50 (CFU/larva) | 95% CI (CFU/larva) | Relative mean potency estimates | Confidence interval for the relative mean potency estimates | Significance |
|---|---|---|---|---|---|---|
24 h | Regular | 5.90 × 105 | 3.87 × 105 – 9.41 × 105 | 2.15 | 1.13–4.50 | Yes |
Persister | 2.75 × 105 | 1.68 × 105 – 4.48 × 105 | 0.47 | 0.22–0.89 | ||
48 h | Regular | 2.32 × 105 | 1.12 × 105 – 5.00 × 105 | 2.04 | 0.71–9.86 | No |
Persister | 1.10 × 105 | 4.61 × 104 – 2.71 × 105 | 0.47 | 0.10–1.41 | ||
72 h | Regular | 2.19 × 105 | 9.57 × 104 – 5.30 × 105 | 2.54 | 0.74–23.85 | No |
Persister | 8.63 × 104 | 3.15 × 104 – 2.52 × 105 | 0.39 | 0.04–1.35 | ||
96 h | Regular | 2.19 × 105 | 9.57 × 104 – 5.30 × 105 | 2.54 | 0.74–23.85 | No |
Persister | 8.63 × 104 | 3.15 × 104 – 2.52 × 105 | 0.39 | 0.04–1.35 | ||
120 h | Regular | 2.19 × 105 | 9.57 × 104- 5.30 × 105 | 2.54 | 0.74–23.85 | No |
Persister | 8.63 × 104 | 3.15 × 104 – 2.52 × 105 | 0.39 | 0.04–1.35 |