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Table 1 MIC50/90 and mode MIC values for imipenem-S, imipenem-NS, and total Pseudomonas aeruginosa and Enterobacterales.a

From: Relebactam restores susceptibility of resistant Pseudomonas aeruginosa and Enterobacterales and enhances imipenem activity against chromosomal AmpC-producing species: analysis of global SMART 2018–2020

Organism

Drug

All Isolates

CLSI

EUCAST

IMI-S Isolates

IMI-NS Isolates

IMI-S Isolates

IMI-NS Isolates

N

MIC50

MIC90

Mode MIC

N

MIC50

MIC90

Mode MIC

N

MIC50

MIC90

Mode MIC

N

MIC50

MIC90

Mode MIC

N

MIC50

MIC90

Mode MIC

Pseudomonas aeruginosa

IMI

23,073

2

32

2

14,717

1

2

2

8356

16

 > 32

16

16,633

2

4

2

6440

16

 > 32

16

IMR

0.5

4

0.5

0.5

0.5

0.5

2

 > 32

1

0.5

1

0.5

2

 > 32

1

Enterobacterales

IMI

91,769

0.25

1

 ≤ 0.12

84,276

0.25

0.5

 ≤ 0.12

7493

 > 8

 > 8

 > 8

86,178

0.25

0.5

 ≤ 0.12

5591

 > 8

 > 8

 > 8

IMR

 ≤ 0.12

0.5

 ≤ 0.12

 ≤ 0.12

0.5

 ≤ 0.12

2

 > 8

 > 8

 ≤ 0.12

0.5

 ≤ 0.12

4

 > 8

 > 8

Chromosomal AmpC producers

IMI

13,003

0.5

2

0.5

11,369

0.5

1

0.5

1634

2

 > 8

2

12,441

0.5

1

0.5

562

 > 8

 > 8

 > 8

IMR

0.25

1

0.25

0.25

0.5

0.25

1

 > 8

0.25

0.25

1

0.25

4

 > 8

 > 8

Enterobacter cloacae

IMI

4784

0.5

1

0.5

4432

0.5

1

0.5

352

8

 > 8

 > 8

4561

0.5

1

0.5

223

 > 8

 > 8

 > 8

IMR

0.25

0.5

0.25

0.25

0.25

0.25

2

 > 8

 > 8

0.25

0.25

0.25

8

 > 8

 > 8

Serratia marcescens

IMI

4013

0.5

2

0.5

3523

0.5

1

0.5

490

2

 > 8

2

3840

0.5

1

0.5

173

8

 > 8

 > 8

IMR

0.5

1

0.5

0.5

1

0.5

2

 > 8

2

0.5

1

0.5

4

 > 8

 > 8

Klebsiella aerogenes

IMI

2653

1

2

1

2030

0.5

1

1

623

2

8

2

2551

1

2

1

102

8

 > 8

4

IMR

0.25

0.5

0.25

0.25

0.5

 ≤ 0.12

0.5

1

0.5

0.25

0.5

0.25

0.5

 > 8

0.5

Citrobacter freundii

IMI

1553

0.5

2

1

1384

0.5

1

1

169

2

 > 8

2

1489

0.5

1

1

64

8

 > 8

4

IMR

0.25

0.5

0.25

0.25

0.25

 ≤ 0.12

0.5

 > 8

0.25

0.25

0.25

0.25

4

 > 8

 > 8

Chromosomal AmpC

nonproducers

IMI

78,766

0.25

1

 ≤ 0.12

72,907

 ≤ 0.12

0.5

 ≤ 0.12

5859

 > 8

 > 8

 > 8

73,737

 ≤ 0.12

0.5

 ≤ 0.12

5029

 > 8

 > 8

 > 8

IMR

 ≤ 0.12

0.5

 ≤ 0.12

 ≤ 0.12

0.25

 ≤ 0.12

2

 > 8

 > 8

 ≤ 0.12

0.25

 ≤ 0.12

4

 > 8

 > 8

Escherichia coli

IMI

46,649

 ≤ 0.12

0.25

 ≤ 0.12

45,843

 ≤ 0.12

0.25

 ≤ 0.12

806

 > 8

 > 8

 > 8

46,004

 ≤ 0.12

0.25

 ≤ 0.12

645

 > 8

 > 8

 > 8

IMR

 ≤ 0.12

0.25

 ≤ 0.12

 ≤ 0.12

0.25

 ≤ 0.12

8

 > 8

 > 8

 ≤ 0.12

0.25

 ≤ 0.12

 > 8

 > 8

 > 8

Klebsiella pneumoniae

IMI

27,423

0.25

 > 8

0.25

22,476

0.25

0.5

0.25

4947

 > 8

 > 8

 > 8

23,125

0.25

0.25

0.25

4298

 > 8

 > 8

 > 8

IMR

0.25

1

 ≤ 0.12

0.25

0.5

 ≤ 0.12

2

 > 8

 > 8

0.25

0.25

 ≤ 0.12

4

 > 8

 > 8

Klebsiella oxytoca

IMI

3329

0.25

0.5

0.25

3238

0.25

0.5

0.25

91

8

 > 8

 > 8

3253

0.25

1

0.25

76

 > 8

 > 8

 > 8

IMR

0.25

0.5

0.25

0.25

0.5

0.25

2

 > 8

 > 8

0.25

0.5

0.25

8

 > 8

 > 8

Citrobacter koseri

IMI

1365

 ≤ 0.12

0.25

 ≤ 0.12

1350

 ≤ 0.12

0.25

 ≤ 0.12

15

4

 > 8

ND

1355

 ≤ 0.12

0.25

 ≤ 0.12

10

8

 > 8

ND

IMR

 ≤ 0.12

0.25

 ≤ 0.12

 ≤ 0.12

0.25

 ≤ 0.12

2

 > 8

ND

 ≤ 0.12

0.25

 ≤ 0.12

4

 > 8

ND

  1. AmpC Ambler class C β-lactamase, CLSI Clinical and Laboratory Standards Institute, EUCAST European Committee on Antimicrobial Susceptibility Testing, IMI Imipenem, IMR imipenem/relebactam, MIC Minimum inhibitory concentration, ND Not detected, NS nonsusceptible, S Susceptible
  2. aIsolates were collected between 2018 and 2020
  3. Bolded MIC values represent MIC50/90 and mode MIC values that were affected by the addition of relebactam to imipenem
  4. N is the number of isolates classified as S or NS for each bacteria species
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BMC Microbiology

ISSN: 1471-2180

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