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Fig. 4 | BMC Microbiology

Fig. 4

From: Relebactam restores susceptibility of resistant Pseudomonas aeruginosa and Enterobacterales and enhances imipenem activity against chromosomal AmpC-producing species: analysis of global SMART 2018–2020

Fig. 4

Effect of relebactam on susceptibility of Pseudomonas aeruginosa and Enterobacterales species to imipenem. A Relebactam restores susceptibility to imipenem in imipenem-NS Pseudomonas aeruginosa and Enterobacterales species. B Relebactam decreases imipenem MIC values in imipenem-S species. C These effects result in increased free drug pharmacokinetic/pharmacodynamic target (%ƒT > MIC) attainment for imipenem. %ƒT, percentage of time of free drug; AmpC, Ambler class C β-lactamase; AUC, area under the concentration–time curve; MIC, minimum inhibitory concentration; NS, nonsusceptible; S, susceptible

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BMC Microbiology

ISSN: 1471-2180

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