Table 3 Affiliation, Name, Function and p value of the 35 gut microbiotic enzymes with significant difference between T2D, PRET2D and Control group
Level 2 | EC ID | Name | Function | p value |
|---|---|---|---|---|
Carbohydrate metabolism | 1.1.1.58 | tagaturonate reductase | pentose and glucuronate interconversions. | 0.049 |
2.3.1.182 | Transferases | C5-Branched dibasic acid metabolism; Valine, leucine and isoleucine biosynthesis. | 0.047 | |
2.4.2.53 | undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase | Amino sugar and nucleotide sugar metabolism. | 0.015 | |
2.6.1.19 | 4-aminobutyrate-2-oxoglutarate transaminase | Butanoate and Propanoate metabolism; Alanine, aspartate, glutamate, beta-Alanine metabolism. | 0.015 | |
2.7.1.1 | Hexokinase | Starch, Sucrose, Glycolysis, Gluconeogenesis, Galactose, Fructose and mannose, Amino sugar and nucleotide sugar metabolism; Streptomycin, Neomycin, kanamycin, gentamicin biosynthesis. | 0.022 | |
2.7.1.55 | allose kinase | Fructose and mannose metabolism. | 0.027 | |
2.8.3.12 | glutaconate CoA-transferase | Butanoate metabolism; Styrene degradation. | Â | |
3.5.99.6 | glucosamine-6-phosphate deaminase | Amino sugar and nucleotide sugar metabolism. | 0.027 | |
4.1.2.17 | Â L-fuculose-phosphate aldolase | Fructose and mannose metabolism. | 0.017 | |
Amino acid metabolism | 1.1.1.103 | Â L-threonine 3-dehydrogenase | Glycine, serine and threonine metabolism. | Â |
2.1.1.104 | caffeoyl-CoA O-methyltransferase | Phenylalanine metabolism; Flavonoid biosynthesis; Phenylpropanoid biosynthesis; Stilbenoid, diarylheptanoid, gingerol biosynthesis. | 0.026 | |
2.8.1.2 | 3-mercaptopyruvate sulfurtransferase | Cysteine and methionine metabolism. | 0.045 | |
3.3.2.12 | oxepin-CoA hydrolase | Phenylalanine metabolism | 0.033 | |
3.5.1.5 | Urease | Arginine biosynthesis; Nucleotide metabolism; Purine metabolism; Atrazine degradation. | 0.017 | |
3.5.2.14 | Â N-methylhydantoinase (ATP-hydrolysing) | Arginine and proline metabolism. | 0.045 | |
4.4.1.1 | cystathionine gamma-lyase | Cysteine and methionine metabolism; Glycine, serine and threonine metabolism; Selenocompound metabolism. | 0.007 | |
5.1.1.4 | proline racemase | Arginine and proline metabolism | 0.020 | |
6.1.1.13 | D-alanine-poly(phosphoribitol) ligase | D-Alanine metabolism. | 0.042 | |
6.3.2.1 | pantoate-beta-alanine ligase (AMP-forming) | beta-Alanine metabolism; Pantothenate and CoA biosynthesis. | 0.018 | |
Metabolism of cofactors and vitamins | 2.1.2.3 | phosphoribosylaminoimidazolecarboxamide formyltransferase | One carbon pool by folate. | 0.046 |
2.1.2.11 | 3-methyl-2-oxobutanoate hydroxymethyltransferase | Pantothenate and CoA biosynthesis. | 0.026 | |
3.5.4.25 | GTP cyclohydrolase II | Riboflavin metabolism; Folate biosynthesis; | 0.038 | |
3.6.1.67 | dihydroneopterin triphosphate diphosphatase | Folate biosynthesis. | 0.043 | |
4.1.99.12 | 3,4-dihydroxy-2-butanone-4-phosphate synthase | Riboflavin metabolism. | 0.036 | |
4.1.99.19 | 2-iminoacetate synthase | Thiamine metabolism. | 0.030 | |
4.3.99.3 | 7-carboxy-7-deazaguanine synthase | Folate biosynthesis. | 0.027 | |
Lipid metabolism | 2.4.1.337 | 1,2-diacylglycerol 3-alpha-glucosyltransferase | Glycerolipid metabolism. | 0.017 |
3.1.4.46 | glycerophosphodiester phosphodiesterase | Glycerophospholipid metabolism. | 0.013 | |
4.2.1.59 | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase | Fatty acid biosynthesis. | 0.020 | |
Nucleotide metabolism | 3.5.4.10 | IMP cyclohydrolase | Purine metabolism. | 0.047 |
Energy metabolism | 1.8.5.3 | respiratory dimethylsulfoxide reductase | Sulfur metabolism. | 0.011 |
| Â | 2.1.1.246 | [methyl-Co (III) methanol-specific corrinoid protein]-coenzyme M methyltransferase | Methane metabolism. | 0.023 |
Metabolism of terpenoids and polyketides | 2.6.1.33 | dTDP-4-amino-4,6-dideoxy-D-glucose transaminase | Polyketide sugar unit biosynthesis; Biosynthesis of other secondary metabolites;Acarbose and validamycin biosynthesis. | 0.007 |
| Â | 5.3.3.2 | sopentenyl-diphosphate Delta-isomerase | Terpenoid backbone biosynthesis. | 0.013 |
Xenobiotics metabolism | 3.5.4.43 | hydroxydechloroatrazine ethylaminohydrolase | Atrazine degradation. | 0.032 |