Virulence of Mycobacterium intracellulare clinical strains in a mouse model of lung infection – role of neutrophilic inflammation in disease severity

Table 1 Characteristics of M. intracellulare strains used in this study

Strain	Genotype^a	Clinical phenotype	Bacterial burden and lung inflammation in C57BL/6 mice	Histological feature
ATCC13950	TMI	Type strain of TMI genotype	Low	Almost no inflammation throughout infection
M.i.198	TMI	Progressive	High	Peribronchovascular and alveolar inflammation
M.i.27	TMI	Stable	Intermediate	Peribronchovascular and alveolar inflammation
M018	TMI	Stable	Intermediate	Peribronchovascular and alveolar inflammation
MOTT64	MP-MIP	Type strain of MP-MIP genotype	Low	Lung inflammation resolved after 8 weeks of infection
M001	MP-MIP	Progressive	Intermediate	Peribronchovascular and alveolar inflammation
M003	MP-MIP	Progressive	Low	Lung inflammation resolved after 8 weeks of infection
M019	MP-MIP	Stable	High	Peribronchovascular and alveolar inflammation
M021	MP-MIP	Stable	High	Peribronchovascular and alveolar inflammation

^aTMI Typical Mycobacterium intracellulare genotype, MP-MIP Mycobacterium paraintracellulare-M. indicus pranii genotype

ISSN: 1471-2180