Fig. 2

Association of microbial features to clinical and nutritional covariates from sputum microbiome. The plot shows bacterial taxa, at genus levels, altered significantly (post hoc FDR < 0.05) in abundance and showing a study effect, compared to baseline and follow-up visits. Signed effect sizes are shown through marker color. Direction of cuneiform plot indicates if taxa were enriched or depleted within the covariate groups (e.g. pwCF with oral Macrolide treatment displayed lower abundance of Neisseria, higher ppFVC correlated positively with increased Neisseria etc.). Size of cuneiform plots indicate significance. Covariates not shown had no difference in rank-transformed values (Cliff’s delta = 0). PPI = proton pump inhibitors, inh = inhalative, iv = intravenous