Table 2 Characteristics of invasive S. pneumoniae isolates with respect to their serotype, MLST profile, resistance to Penicillin, Cefotaxim Tetracyclin and Erythromycin, the source of isolation and transposon types
Serotypes (N°of isolates) | Predicted ST/CC (N°of isolates) | Associated PMEN clone | Year ()a | PeniGb ()a | Ctxc ()a | Tetd ()a | Erye ()a | Source of isolation ()a | MLSB ()a | ermB/mefE ()a | Transposon ()a |
|---|---|---|---|---|---|---|---|---|---|---|---|
14 (18) | 2918 (11) | Spain9V-3, SLVj ST156 | 2013 (2) 2014 (1) 2015 (1) 2016 (4) 2017 (2) 2018 (1) | Ih (9) R (2) | I (4) S (7) | Sg (9) R (2) | Ri(10) S(1) | Blood (6) CSFf (3) Puncture fluid (1) | MLSBc (10) | ermB (10) | Tn1545 (10) |
143 (3) | Spain9 V-3 DLVk ST156 | 2012 (1) 2016 (1) 2018 (1) | I (1) R (2) | I (2) S (1) | I (1) S (2) | R (3) | Blood (2) Puncture fluid (1) | MLSBc (1) M (2) | ermB (1) mef E (2) | Tn1545 (1) Tn2009 (2) | |
4949 (1) | Spain9V-3, DLV ST156 | 2014 | R | S | S | R | Blood | MLSBc | ermB | Tn1545 | |
63 (1) | 2012 | I | S | R | S | CSF | |||||
156 (1) | Spain9 V-3 | 2015 | I | S | S | S | Blood | ||||
4344 (1) | 2015 | I | S | S | S | Blood | |||||
19F (15) | 179 (13) | Portugal19F21, SLV ST177 | 2012 (2) 2013 (6) 2014 (2) 2015 (1) 2017 (2) | I (9) R (4) | I (6) S(7) | R (8) I (2) S (3) | R(12) S (1) | Abscess (1) Blood (3) CSF (7) Puncture fluid (1) Deep pus(1) | MLSBc (11) MLSBi (1) | ermB (12) | Tn1545 (11) Tn6002 (1) |
2307 (1) | 2014 | I | I | S | R | Blood | MLSBc | ermB | Tn1545 | ||
16,235 (1) | Portugal19F- 21, DLV ST177 | 2016 | I | S | R | R | Blood | MLSBc | ermB | Tn1545 | |
3 | 1220 (3) | 2013 (1) | S (3) | S (3) | I (1) | R (2) | Blood (2) | MLSBc | ermB (2) | Tn6002 (2) | |
(12) | 2016 (1) | S (2) | S(1) | Deep pus (1) | (2) | ||||||
2018 (1) | |||||||||||
16,168 (1) | 2018 | S | S | R | R (1) | Blood | MLSBc | ermB | Tn1545 | ||
180 (4) | 2012 | S (4) | S (4) | S (4) | S (4) | Blood (2) | |||||
2014 | Deep pus (1) | ||||||||||
2015 | Abscess (1) | ||||||||||
2017 | |||||||||||
260 (2) | 2016 (2) | S (2) | S (2) | S (2) | S (2) | Blood (2) | |||||
505 (2) | 2014 | S (2) | S (2) | S (2) | S (2) | Blood (1) | |||||
2018 | Puncture fluid (1) | ||||||||||
6B | 386 (5) | Poland6B- | 2013 (1) | I (4) | S (5) | R (4) | R (5) | Blood (2) | MLSBc | ermB (4) | Tn1545 (4) |
(8) | 20, DLV | 2016 (1) | S (1) | S (1) | CSF (2) | (4) | Tn6002 (1) | ||||
ST315 | 2017 (1) | Deep pus (1) | MLSBi | ||||||||
2018 (2) | (1) | ||||||||||
9194 (1) | 2013 | S | S | R | R | Blood | MLSBc | ermB | Tn1545 | ||
16,104 (1) | 2013 | I | S | R | R | Ascite fluid | MLSBc | ermB | Tn1545 | ||
16,106 (1) | 2015 | I | S | S | S | Puncture fluid | |||||
6A (8) | 2105 (2) | Sweden15A-25, SLV ST63 | 2016 (1) 2018 (1) | I (2) | S (2) | R (2) | R(2) | Blood (1) CSF (1) | MLSBc (2) | ermB (2) | Tn6003 (2) |
2467 (1) | 2015 | I | S | S | R | Blood | MLSBi | ermB | Tn6002 | ||
5679 (1) | 2013 | I | S | S | R | Blood | MLSBi | ermB + mefE | Tn2010 | ||
16,103 (1) | 2014 | I | S | S | R | Blood | M | mefE | Tn2009 | ||
16,105 (1) | 2013 | I | S | S | R | CSF | M | mefE | Tn2009 | ||
172 (2) | 2017 | I (1) | S (2) | S (2) | S (2) | Blood | |||||
2018 | S (1) | CSF | |||||||||
9 V (6) | 156 (2) | Spain9V-3 ST156 | 2012 2015 | I (2) | S (2) | R (1) (S1) | R(1) S (1) | Blood (2) | MLSBi | ermB | Tn1545 |
838 (2) | Spain9V-3, SLV ST156 | 2013 | R (1) | S (2) | R (1) | R (1) | Blood (1) | MLSBc | ermB | Tn1545 | |
2018 | I (1) | S (1) | S (1) | CSF (1) | |||||||
280 (2) | 2013 2016 | S (2) | S (2) | S(2) | S (2) | CSF (2) | |||||
18C | 1381 (1) | 2016 | I | S | R | R | CSF | MLSBc | ermB | Tn1545 | |
(6) | 280 (1) | 2018 | S | S | S | R | CSF | M | mefE | Tn2009 | |
1233 (3) | 2013 2014 2015 | S(3) | S (3) | S (3) | S (3) | Blood (1) Puncture fluid (1) CSF (1) | |||||
241 (1) | 2016 | S | S | S | S | Blood | |||||
19A (5) | 3772 (5) | Denmark14- 32 DLV ST230 | 2012 (1) 2016 (2) 2017 (1) 2018 (1) | I (4) R (1) | I (1) S (4) | R (3) I (1) S (1) | R (4) I (1) | Blood (5) | MLSBc (1) MLSBi (3) | ermB (4) | Tn1545 (4) |
23F (4) | 4003 (3) | Spain23F--1, SLV ST81 | 2014 (1) 2015 (1) 2016 (1) | I (3) | I (2) S (1) | S (3) | R (3) | Blood (2) CSF (1) | MLSBc (3) | ermB (3) | Tn1545 (3) |
81 (1) | Spain23F-1 ST81 | 2012 | I | S | R | R | Blood | MLSBc | ermB | Tn1545 | |
9A (3) | 6521 (3) | Spain9 V-3 DLV ST156 | 2012 (1) 2013 (1) 2014 (1) | I (2) R (1) | S (3) | R (3) | R (3) | Blood (3) | MLSBc (3) | ermB (3) | Tn1545 (3) |
9 N (3) | 6359 (1) | 2018 | I | S | R | R | Pleural fluid | MLSBc | ermB | Tn1545 | |
8809 (1) | 2017 | I | S | S | S | CSF | |||||
517 (1) | 2018 | S | S | R | R | Blood | MLSBc | ermB | Tn1545 | ||
35B (3) | 558 (3) | Utah35B24, SLV ST377 | 2013 (1) 2015 (2) | I (3) | S (2) I (1) | S (3) | R (2) S(1) | Blood (2) CSF (1) | M (2) | mefE (2) | Tn2009 (2) |
17F (3) | 4847 (1) 13,010 (2) | 2013 2016 2018 | S S I | S S S | S S S | R S S | Blood Blood Blood | ||||
16F (2) | 383 3551 | 2016 2018 | S | S | S | S S | Abscess CSF | ||||
4 (2) | 17,458 205 | Sweeden4- 38 ST205 | 2015 2016 | S | S | S | S S | Puncture fluid Blood | |||
1 (1) | 17,380 | Sweden1- 28, DLV ST306 | 2014 | S | S | S | S | Blood | |||
24F (1) | 16,415 | Denmark14 −32, DLV ST230 | 2018 | S | S | R | R | Puncture fluid | MLSBc | ermB | Tn1545 |
34 (1) | 2601 | 2015 | S | S | S | S | CSF | ||||
13 (1) | 2187 | 2013 | S | S | S | S | CSF | ||||
35F (1) | 15,108 | 2016 | I | S | S | S | CSF | ||||
7F (1) | 17,442 | Denmark12 F-24, DLV ST218 | 2014 | S | S | S | S | Blood | |||
7C (1) | 1201 | 2014 | S | S | S | S | CSF | ||||
6C (1) | 386 | Poland6B- 20, DLV ST315 | 2014 | I | S | R | R | Abscess | MLSBc | ermB | Tn6002 |