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Table 2 The effect of nagZ on MICs for six anbiotics

From: Cefazolin and imipenem enhance AmpC expression and resistance in NagZ-dependent manner in Enterobacter cloacae complex

Antibiotics

MIC(μg/ml)

WT

ΔnagZ

ΔnagZ + CFZ

(4 μg/ml)

ΔnagZ + IMP

(0.0625 μg/ml)

ΔnagZ + NagZ

ΔnagZ + NagZ + 

CFZ(256 μg/ml)

ΔnagZ + NagZ + 

IMP(0.125 μg/ml)

PIP

64

2

2

1

32

256

512

TZP

32

2

1

0.5

32

128

512

ATM

32

1

1

0.5

16

256

512

CRO

16

0.5

0.5

0.25

32

64

1024

CAZ

16

0.5

0.5

0.25

16

64

128

SCF

4

0.25

0.125

0.0625

4

64

64

  1. Abbreviations: ΔnagZ nagZ-knockout Enterobacter cloacae complex, ΔnagZ + CFZ ΔnagZ treated with CFZ, ΔnagZ + IMP ΔnagZ treated with IMP, ΔnagZ + NagZ + CFZ ΔnagZ + NagZ treated with CFZ, ΔnagZ + NagZ + IMP ΔnagZ + NagZ treated with IMP
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BMC Microbiology

ISSN: 1471-2180

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