Fig. 7

Genome tree heat map of sensing modules of the SigB general stress for 19 Bacillus subtilis genomes and 106 Bacillales members. The heat map of the core genome tree of sensing modules of the SigB general stress for 19 Bacillus subtilis genomes and 106 Bacillales members was generated using iTOL (PMID27095192) [54]. The tree on the left shows the phylogenetic relationships of all genomes based on the core conserved protein sequences in each genome. The tree on the top shows the clustering of genes involved in SigB signal sensing. The red squares indicates the presence of a target gene, and the intensity of the red color indicates the gene copy number. White indicates the absence of a gene. Underlying background data are shown in Supplementary Table S7. The insert shows the summary of the general distribution of the three sensing modules for each species belonging to the Bacillales order. Stressosome refers to the rsbRST stressosome genes and stressosome downstream elements to rsbV, rsbW and sigB. The energy branch refers to the rsbQP genes and the two-component to the rsbKY genes. Inspected strains that contain only a single gene of a signaling module, e.g., the presence of an orphan rsbK gene without its cognate response regulator gene rsbY, or the presence of a rsbP phosphatase gene without its partner rsbQ, are referred to as having a partial two-component, or a partial energy system, respectively. Other SigB sensors and regulators included the blue light sensor (YtvA), the regulator of SigB methyltransferase BC1007 (renamed to RsbM by Chen et al., [27]), and the feedback regulator RsbX phosphoserine phosphatase. Underlying background data are shown in Supplementary Table S7