Table 7 The minimal inhibitory concentration (MIC) distribution of ceftobiprole when tested against different clinically isolated strains in China
Organisms (no.) | Cumulative percentage of isolates at MIC (mg/L, %) | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
≤ 0.015 | 0.03 | 0.06 | 0.125 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | 32 | 64 | 128 | > 128 | |
a | |||||||||||||||
MRSA (55) | 0.0 | 0.0 | 0.0 | 0.0 | 5.5 | 27.3 | 80.0 | 100.0 | – | – | |||||
MSSA (55) | 0.0 | 0.0 | 0.0 | 0.0 | 1.8 | 69.1 | 98.2 | 100.0 | – | – | |||||
MRCNS (40) | 10.0 | 10.0 | 10.0 | 10.0 | 12.5 | 40.0 | 87.5 | 95.0 | 100.0 | – | – | ||||
MSCNS (40) | 5.0 | 5.0 | 15.0 | 32.5 | 65.0 | 97.5 | 100.0 | – | – | ||||||
E. faecalis (24) | 0.0 | 0.0 | 4.2 | 4.2 | 25.0 | 66.7 | 91.7 | 91.7 | 91.7 | 91.7 | 91.7 | 91.7 | 100.0 | – | – |
E. faecium (23) | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.3 | 8.7 | 17.4 | 17.4 | 17.4 | 17.4 | 17.4 | 100.0 | – | – |
S. pyogenes (13) | 100.0 | – | – | ||||||||||||
S. agalactiae (14) | 100.0 | – | – | ||||||||||||
S. mitis (12) | 58.3 | 58.3 | 75.0 | 75.0 | 75.0 | 83.3 | 83.3 | 100.0 | – | – | |||||
PSSP (110) | 24.5 | 28.2 | 40.0 | 55.5 | 74.5 | 98.2 | 100.0 | – | – | ||||||
PISP (25) | 0.0 | 0.0 | 0.0 | 4.0 | 8.0 | 52.0 | 100.0 | – | – | ||||||
PRSP (13) | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 53.8 | 84.6 | 92.3 | 92.3 | 92.3 | 92.3 | 100.0 | – | – | |
H. influenzae (53) | 71.2 | 76.9 | 76.9 | 82.7 | 86.5 | 96.2 | 100.0 | – | – | ||||||
M. catarrhalis (49) | 0.0 | 0.0 | 18.4 | 38.8 | 71.4 | 98.0 | 100.0 | – | – | ||||||
E. coli (ESBL-) (49) | – | – | 59.2 | 89.8 | 91.8 | 95.9 | 95.9 | 100.0 | |||||||
E. coli (ESBL +) (50) | – | – | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 4.0 | 4.0 | 4.0 | 6.0 | 8.0 | 8.0 | 8.0 | 100.0 |
b | |||||||||||||||
K. pneumonia (ESBL-) (56) | – | – | 80.4 | 87.5 | 98.2 | 98.2 | 98.2 | 98.2 | 98.2 | 98.2 | 98.2 | 98.2 | 98.2 | 98.2 | 100.0 |
K. pneumonia (ESBL +) (58) | – | – | 5.2 | 5.2 | 6.9 | 6.9 | 6.9 | 6.9 | 6.9 | 8.6 | 10.3 | 12.1 | 12.1 | 13.8 | 100.0 |
CR-KPN (45) | – | – | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 100.0 |
E. cloacae (49) | – | – | 40.8 | 49.0 | 49.0 | 57.1 | 61.2 | 61.2 | 63.3 | 67.3 | 67.3 | 69.4 | 69.4 | 69.4 | 100.0 |
E. aerogenes (55) | – | – | 54.5 | 74.5 | 80.0 | 83.6 | 85.5 | 85.5 | 87.3 | 87.3 | 87.3 | 87.3 | 87.3 | 89.1 | 100.0 |
C. freudii (53) | – | – | 50.9 | 58.5 | 64.2 | 64.2 | 66.0 | 69.8 | 71.7 | 71.7 | 71.7 | 71.7 | 71.7 | 73.6 | 100.0 |
P. mirabilis (52) | – | – | 55.8 | 65.4 | 65.4 | 65.4 | 65.4 | 67.3 | 67.3 | 67.3 | 69.2 | 69.2 | 69.2 | 71.2 | 100.0 |
P. vulgaris (35) | – | – | 17.1 | 17.1 | 17.1 | 17.1 | 20.0 | 25.7 | 31.4 | 34.3 | 54.3 | 60.0 | 80.0 | 88.6 | 100.0 |
M. morganella (53) | – | – | 65.5 | 78.2 | 80.0 | 83.6 | 85.5 | 87.3 | 87.3 | 87.3 | 87.3 | 96.4 | 100.0 | ||
S. marcescens (53) | – | – | 9.6 | 38.5 | 71.2 | 80.8 | 84.6 | 88.5 | 88.5 | 90.4 | 90.4 | 90.4 | 90.4 | 90.4 | 100.0 |
CS-PAE (19) | – | – | 0.0 | 0.0 | 0.0 | 0.0 | 10.5 | 26.3 | 47.4 | 84.2 | 89.5 | 89.5 | 89.5 | 89.5 | 100.0 |
CR-PAE (19) | – | – | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 10.5 | 52.6 | 84.2 | 89.5 | 94.7 | 94.7 | 100.0 |
CS-ABA (17) | – | – | 0.0 | 0.0 | 41.2 | 64.7 | 88.2 | 88.2 | 94.1 | 94.1 | 94.1 | 94.1 | 94.1 | 94.1 | 100.0 |
CR-ABA (19) | – | – | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 5.3 | 5.3 | 5.3 | 5.3 | 10.5 | 26.3 | 100.0 |