Antimicrobial activity of ceftobiprole and comparator agents when tested against gram-positive and -negative organisms collected across China (2016–2018)

Table 6 Activity of ceftobiprole and comparator antimicrobial agents when tested against Pseudomonas aeruginosa and Acinetobacter baumanni isolated from China (mg/L)

Antimicrobial agents	MIC Range	MIC₅₀	MIC₉₀	R%	S%
Carbapenem-susceptible *Pseudomonas aeruginosa* (19)
Ceftobiprole	1 – > 128	8	> 128	–	–
Ceftazidime	1 – > 128	4	> 128	10.5	68.4
Cefoperazone-Sulbactam	0.25 – > 128	4	64	10.5	84.2
Imipenem	0.25 – 4	0.5	4	0	84.2
Amikacin	0.5 – > 128	2	> 128	10.5	89.5
Colistin	0.5 – 2	1	2	0	100
Carbapenem-resistant *Pseudomonas aeruginosa* (19)
Ceftobiprole	4 – > 128	8	64	–	–
Ceftazidime	8 – 64	16	64	36.8	26.3
Cefoperazone-Sulbactam	1 – 128	64	128	52.6	36.8
Imipenem	4 – 64	4	32	47.4	0
Amikacin	1 – > 128	2	16	5.3	94.7
Colistin	0.5 – 1	1	1	0	100
Carbapenem-susceptible **Acinetobacter baumanni (17)**
Ceftobiprole	0.25 – > 128	0.5	4	–	–
Ceftazidime	2 – 64	8	8	5.9	94.1
Cefoperazone-Sulbactam	1 – 64	1	2	5.9	94.1
Imipenem	≤ 0.06 – 0 .5	0.125	0.25	0	100
Amikacin	0.25 – 16	1	4	0	100
Colistin	0.25 – 2	0.5	1	0	100
Tigecycline	0.25 – 1	0.25	1	0	100
Carbapenem-resistant **Acinetobacter baumanni (19)**
Ceftobiprole	4 – > 128	> 128	> 128	–	–
Ceftazidime	32 – > 128	128	> 128	100	0
Cefoperazone-Sulbactam	16 – 128	64	64	52.6	36.8
Imipenem	4 – 128	16	32	89.5	0
Amikacin	1 – > 128	> 128	> 128	84.2	15.8
Colistin	0.5 – 2	0.5	2	0	100
Tigecycline	0.5 – 4	1	2	0	94.7

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