Table 5 Activity of ceftobiprole and comparator antimicrobial agents when tested against Enterobacteriaceae isolated from China (mg/L)

a

Escherichia coli (ESBL-) (49)

 Ceftobiprole

 ≤ 0.06 – 2

 ≤ 0.06

0.25

8.2

91.8

 Ceftazidime

 ≤ 0.06 – 2

0.25

2

0

100

 Ceftriaxone

 ≤ 0.06 – 8

 ≤ 0.06

0.25

2

98

 Cefoperazone-Sulbactam

 ≤ 0.06 – 32

0.5

8

0

98

 Imipenem

 ≤ 0.06 – 0.25

0.125

0.125

0

100

 Amikacin

0.5 – > 128

1

4

2

98

 Colistin

0.25 – 4

0.5

0.5

2

98

 Tigecycline

0.125 – 1

0.25

0.5

0

100

Escherichia coli (ESBL +) (50)

 Ceftobiprole

1 – > 128

 > 128

 > 128

100

0

 Ceftazidime

4 – > 128

16

128

64

14

 Ceftriaxone

4 – > 128

 > 128

 > 128

100

0

 Cefoperazone-Sulbactam

2 – > 128

16

64

20

58

 Imipenem

 ≤ 0.06 – 0.5

0.125

0.25

0

100

 Amikacin

0.5 – > 128

2

128

12

88

 Colistin

0.25 – 4

0.5

1

4

96

 Tigecycline

0.125 – 1

0.25

0.5

0

100

Klebsiella pneumonia (ESBL-) (56)

 Ceftobiprole

 ≤ 0.06 – > 128

 ≤ 0.06

0.25

1.8

98.2

 Ceftazidime

 ≤ 0.06 – 32

0.25

2

3.6

96.4

 Ceftriaxone

 ≤ 0.06 – > 128

 ≤ 0.06

0.125

1.8

98.2

 Cefoperazone-Sulbactam

 ≤ 0.06 – 16

0.25

1

0

100

 Imipenem

 ≤ 0.06 – 0.5

0.125

0.25

0

100

 Amikacin

0.25 – > 128

0.5

1

1.8

98.2

 Colistin

0.25 – > 32

0.5

1

1.8

98.2

 Tigecycline

0.25 – 16

1

1

1.8

96.4

Klebsiella pneumonia (ESBL +) (58)

 Ceftobiprole

 ≤ 0.06 – > 128

 > 128

 > 128

93.1

6.9

 Ceftazidime

2 – > 128

16

 > 128

65.5

6.9

 Ceftriaxone

0.25 – > 128

 > 128

 > 128

94.8

3.4

 Cefoperazone-Sulbactam

0.5 – > 128

32

128

32.8

48.3

 Imipenem

 ≤ 0.06 – 1

0.125

0.5

0

100

 Amikacin

0.25 – > 128

1

 > 128

10.3

89.7

 Colistin

0.25 – > 32

0.5

1

3.4

96.6

 Tigecycline

0.125 – 16

1

2

1.7

91.4

b

Carbapenem-resistant Klebsiella pneumonia (45)

 Ceftobiprole

 > 128 – > 128

 > 128

 > 128

100

0

 Ceftazidime

16 – > 128

 > 128

 > 128

100

0

 Ceftriaxone

4 – > 128

 > 128

 > 128

100

0

 Cefoperazone-Sulbactam

64 – > 128

 > 128

 > 128

100

0

 Imipenem

2 – 128

16

64

86.7

0

 Amikacin

0.25 – > 128

 > 128

 > 128

60

40

 Colistin

0.25 – > 32

0.5

2

8.9

91.1

 Tigecycline

0.25 – 2

1

2

0

100

Enterobacter cloacae (49)

 Ceftobiprole

 ≤ 0.06 – > 128

0.5

 > 128

51

49

 Ceftazidime

0.125 – > 128

2

 > 128

36.7

59.2

 Ceftriaxone

 ≤ 0.06 – > 128

1

 > 128

46.9

51

 Cefoperazone-Sulbactam

 ≤ 0.06 – > 128

4

 > 128

22.4

65.3

 Imipenem

 ≤ 0.06 – 4

0.5

4

12.2

87.8

 Amikacin

0.5 – > 128

1

4

2

95.9

 Colistin

0.25 – 4

0.5

2

4.1

95.9

 Tigecycline

0.25 – 8

1

2

2

93.9

Enterobacter aerogenes (55)

 Ceftobiprole

 ≤ 0.06 – > 128

 ≤ 0.06

 > 128

20

80

 Ceftazidime

0.125 – 128

1

32

29.1

70.9

 Ceftriaxone

 ≤ 0.06 – > 128

0.25

 > 128

27.3

70.9

 Cefoperazone-Sulbactam

 ≤ 0.06 – 128

0.5

64

10.9

83.6

 Imipenem

 ≤ 0.06 – 4

0.5

1

1.8

98.2

 Amikacin

0.125 – 8

1

2

0

100

 Colistin

0.125 – 4

0.5

1

1.8

98.2

 Tigecycline

0.25 – 4

1

1

0

92.7

Citrobacter freudii (53)

 Ceftobiprole

 ≤ 0.06 – > 128

 ≤ 0.06

 > 128

35.8

64.2

 Ceftazidime

0.25 – > 128

2

128

32.1

60.4

 Ceftriaxone

 ≤ 0.06 – > 128

0.5

 > 128

37.7

60.4

 Cefoperazone-Sulbactam

0.125 – > 128

1

 > 128

20.8

71.7

 Imipenem

 ≤ 0.06 – 4

0.5

1

3.8

90.6

 Amikacin

0.125 – > 128

2

4

1.9

98.1

 Colistin

0.25 – 4

0.5

2

1.9

98.1

 Tigecycline

0.25 – 4

0.5

1

0

98.1

c

Proteus mirabilis (52)

 Ceftobiprole

 ≤ 0.06 – > 128

 ≤ 0.06

 > 128

34.6

65.4

 Ceftazidime

 ≤ 0.06 – 2

 ≤ 0.06

0.25

0

100

 Ceftriaxone

 ≤ 0.06 – 128

 ≤ 0.06

16

26.9

73.1

 Cefoperazone-Sulbactam

0.25 – 4

1

4

0

100

 Imipenem

 ≤ 0.06 – 2

0.5

1

0

94.2

 Amikacin

0.5 – 32

2

8

0

98.1

 Colistin

32 – > 32

 > 32

 > 32

100

0

 Tigecycline

1 – 8

2

4

9.6

71.2

Proteus vulgaris (35)

 Ceftobiprole

 ≤ 0.06 – > 128

32

 > 128

82.9

17.1

 Ceftazidime

 ≤ 0.06 – 64

 ≤ 0.06

1

5.7

94.3

 Ceftriaxone

 ≤ 0.06 – > 128

 ≤ 0.06

32

20

74.3

 Cefoperazone-Sulbactam

0.5 – 64

1

4

8.6

91.4

 Imipenem

0.25 – 32

1

2

5.7

88.6

 Amikacin

0.5 – 16

2

8

0

100

 Colistin

32 – > 32

 > 32

 > 32

100

0

 Tigecycline

0.5 – 4

2

4

0

88.6

Morganella morganella (53)

 Ceftobiprole

 ≤ 0.06 – 64

 ≤ 0.06

32

20

80

 Ceftazidime

 ≤ 0.06 – 32

0.125

2

7.3

92.7

 Ceftriaxone

 ≤ 0.06 – > 128

 ≤ 0.06

8

16.4

80

 Cefoperazone-Sulbactam

0.125 – 8

1

4

0

100

 Imipenem

0.125 – 2

1

2

0

69.1

 Amikacin

0.5 – > 128

2

8

1.8

98.2

 Colistin

32 – > 32

 > 32

 > 32

100

0

 Tigecycline

0.25 – 4

1

2

0

92.7

Serratia marcescens (53)

 Ceftobiprole

 ≤ 0.06 – > 128

0.25

8

28.8

71.2

 Ceftazidime

 ≤ 0.06 – 32

0.5

2

3.8

92.3

 Ceftriaxone

 ≤ 0.06 – > 128

0.25

16

13.5

80.8

 Cefoperazone-Sulbactam

0.5 – > 128

2

32

7.7

88.5

 Imipenem

0.125 – 1

0.5

1

0

100

 Amikacin

0.5 – > 128

2

8

1.9

96.2

 Colistin

 > 32 – > 32

 > 32

 > 32

100

0

 Tigecycline

0.5–2

1

1

0

100