Antimicrobial activity of ceftobiprole and comparator agents when tested against gram-positive and -negative organisms collected across China (2016–2018)

Table 4 Activity of ceftobiprole and comparator antimicrobial agents when tested against Haemophilus influenzae and Moraxella catarrhalis isolated from China (mg/L)

Antimicrobial agents	MIC Range	MIC₅₀	MIC₉₀	R%	S%
*Haemophilus influenzae* (53)
Ceftobiprole	≤ 0.015 – 1	≤ 0.015	0.5	–	–
Ampicillin	0.03 – 32	1	32	44.2	51.9
Ampicillin-Sulbactam	0.06 – 4	1	2	5.8	94.2
Cefuroxime	0.25 – 16	1	2	1.9	98.1
Ceftazidime	≤ 0.015 – 2	0.06	0.5	0	100
Ceftriaxone	≤ 0.015 – .5	≤ 0.015	0.25	0	100
Ciprofloxacin	≤ 0.015 – 4	≤ 0.015	0.5	1.9	98.1
Azithromycin	≤ 0.015 – > 32	1	> 32	40.4	59.6
*Moraxella catarrhalis* (49)
Ceftobiprole	0.06 – 1	0.25	0.5	–	–
Ampicillin	0.5 – 32	2	16	4.1	89.8
Ampicillin-Sulbactam	0.06 – 0 .5	0.125	0.25	0	100
Cefuroxime	0.125 – 8	2	4	0	93.9
Ceftazidime	0.06 – 0.25	0.06	0.25	0	100
Ceftriaxone	0.06 – 2	0.5	2	0	100
Ciprofloxacin	≤ 0.015 – 1	0.06	0.5	0	100
Azithromycin	0.06 – > 32	1	> 32	67.3	32.7

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