Table 3 Activity of ceftobiprole and comparator antimicrobial agents when tested against Streptococcus isolated from China (mg/L)
Antimicrobial agents | MIC Range | MIC50 | MIC90 | R% | S% |
|---|---|---|---|---|---|
Streptococcus pyogenes (13) | |||||
Ceftobiprole | ≤ 0.015 – ≤ 0.015 | ≤ 0.015 | ≤ 0.015 | – | – |
Linezolid | 0.25 – 0 .25 | 0.25 | 0.25 | 0 | 100 |
Vancomycin | 0.125 – 0 .25 | 0.25 | 0.25 | 0 | 100 |
Penicillin | ≤ 0.015 – 0.06 | ≤ 0.015 | 0.03 | 0 | 100 |
Ciprofloxacin | 0.125 – 1 | 0.25 | 0.25 | ||
Erythromycin | 64 – > 128 | > 128 | > 128 | 100 | 0 |
Streptococcus agalactiae (14) | |||||
Ceftobiprole | ≤ 0.015 – ≤ 0.015 | ≤ 0.015 | ≤ 0.015 | – | – |
Linezolid | 0.25 – 0.5 | 0.25 | 0.5 | 0 | 100 |
Vancomycin | 0.25 – 0 .25 | 0.25 | 0.25 | 0 | 100 |
Penicillin | ≤ 0.015 – 0.125 | 0.03 | 0.125 | 0 | 100 |
Ciprofloxacin | 0.25 – 16 | 0.5 | 16 | – | – |
Erythromycin | ≤ 0.06 – > 128 | > 128 | > 128 | 64.3 | 35.7 |
Streptococcus mitis (12) | |||||
Ceftobiprole | ≤ 0.015 – 2 | ≤ 0.015 | 2 | – | – |
Linezolid | ≤ 0.06 – 0.5 | 0.25 | 0.25 | 0 | 100 |
Vancomycin | 0.25 – 0.5 | 0.25 | 0.5 | 0 | 100 |
Penicillin | ≤ 0.015 – 2 | 0.06 | 2 | 0 | 58.3 |
Ciprofloxacin | 0.5 – 32 | 2 | 4 | – | – |
Erythromycin | ≤ 0.06 – > 128 | 1 | > 128 | 66.7 | 33.3 |
Streptococcus pneumonia (MIC of Penicillin ≤ 2 mg/L) (PSSP) (110) | |||||
Ceftobiprole | ≤ 0.015 – 1 | 0.125 | 0.5 | 1.8 | 98.2 |
Linezolid | ≤ 0.06 – 2 | 0.5 | 1 | 0 | 100 |
Vancomycin | ≤ 0.06 – 0.25 | 0.125 | 0.25 | 0 | 100 |
Penicillin | ≤ 0.015 – 2 | 0.5 | 2 | 0 | 100 |
Ciprofloxacin | 0.03 – 16 | 0.5 | 1 | – | – |
Erythromycin | ≤ 0.06 – > 128 | > 128 | > 128 | 90.9 | 5.5 |
Streptococcus pneumonia (MIC of Penicillin = 4 mg/L) (PISP) (25) | |||||
Ceftobiprole | 0.125 – 1 | 0.5 | 1 | 48 | 52 |
Linezolid | 0.125 – 2 | 0.5 | 1 | 0 | 100 |
Vancomycin | ≤ 0.06 – 0.25 | 0.25 | 0.25 | 0 | 100 |
Penicillin | 4 – 4 | 4 | 4 | 0 | 0 |
Ciprofloxacin | 0.25 – 2 | 1 | 2 | – | – |
Erythromycin | 2 – > 128 | > 128 | > 128 | 100 | 0 |
Streptococcus pneumonia (MIC of Penicillin ≥ 8 mg/L) (PRSP) (13) | |||||
Ceftobiprole | 0.5 – 32 | 0.5 | 2 | 46.2 | 53.8 |
Linezolid | 0.125 – 1 | 0.25 | 1 | 0 | 100 |
Vancomycin | 0.125 – 0.25 | 0.125 | 0.25 | 0 | 100 |
Penicillin | 8 – 32 | 8 | 16 | 100 | 0 |
Ciprofloxacin | 0.5 – 8 | 1 | 4 | – | – |
Erythromycin | 4 – > 128 | > 128 | > 128 | 100 | 0 |